Static Magnetic Field Stimulation over the Visual Cortex Increases Alpha Oscillations and Slows Visual Search in Humans
Static Magnetic Field Stimulation over the Visual Cortex Increases Alpha Oscillations and Slows Visual Search in Humans
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DOI：
10.1523/jneurosci.4232-14.2015
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发表时间：
2015-06-17
影响因子：
5.3
通讯作者：
Oliviero, Antonio
中科院分区：
文献类型：
--
作者：
Gonzalez-Rosa, Javier J.;Soto-Leon, Vanesa;Oliviero, Antonio
经颅静磁场刺激(TSMS)是近年来发展起来的一种无创、便携的调节人脑兴奋性的方法。然而，尽管有证据表明静态磁场会干扰动物的神经功能，但目前还缺乏证明静态磁场可以影响人类大脑活动和行为的证据。在这里，我们表明，经颅施加一个静态磁场(120-200mT，距磁体表面2-3厘米)在人的枕骨上产生一个焦点增加的阿尔法振荡的功率在下面的皮质。关键的是，TSM的这种神经生理效应与视觉搜索任务中表现缓慢的平行，选择性地用于最困难的目标检测试验。在TSMS期间，后皮质区域的刺激前阿尔法功率与对目标的反应时间(RT)之间的典型关系被改变，使得在困难但不容易的目标检测试验中，依赖于TSM的阿尔法功率的增加与更长的反应时间相关。我们的结果直接证明，放置在头皮上的强大磁铁可以调节正常的大脑活动，并诱导人类的行为变化。
Transcranial static magnetic field stimulation (tSMS) was recently introduced as a promising tool to modulate human cerebral excitability in a noninvasive and portable way. However, a demonstration that static magnetic fields can influence human brain activity and behavior is currently lacking, despite evidence that static magnetic fields interfere with neuronal function in animals. Here we show that transcranial application of a static magnetic field (120-200 mT at 2-3 cm from the magnet surface) over the human occiput produces a focal increase in the power of alpha oscillations in underlying cortex. Critically, this neurophysiological effect of tSMS is paralleled by slowed performance in a visual search task, selectively for the most difficult target detection trials. The typical relationship between prestimulus alpha power over posterior cortical areas and reaction time (RT) to targets during tSMS is altered such that tSMS-dependent increases in alpha power are associated with longer RTs for difficult, but not easy, target detection trials. Our results directly demonstrate that a powerful magnet placed on the scalp modulates normal brain activity and induces behavioral changes in humans.