Serum amyloid A as indicator of distant metastases but not as early tumor marker in patients with renal cell carcinoma
Serum amyloid A as indicator of distant metastases but not as early tumor marker in patients with renal cell carcinoma
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DOI：
10.1016/j.canlet.2008.04.022
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发表时间：
2008-09-28
期刊：
影响因子：
9.7
通讯作者：
Jung, Klaus
中科院分区：
文献类型：
--
作者：
Ramankulov, Azizbek;Lein, Michael;Jung, Klaus
本研究旨在探讨肾细胞癌（RCC）患者血清淀粉样蛋白A（SAA）浓度的临床意义。采用酶联免疫吸附法检测55例正常人和98例肾癌患者血清SAA蛋白水平，其中肾癌患者分为局限性组（N0 M0，n = 40）、淋巴结转移组（N1 M0，n = 13）和远处转移组（M1，n = 45）。对照组和NOW组的SAA浓度无显著性差异，但M1组SAA浓度显著高于N1M0和N0M0组。在这方面，SAA提供了一个准确的检测远端转移的ROC曲线下面积为0.86。使用多变量考克斯比例风险回归模型，SAA被确定为RCC患者生存的重要独立因素。SAA可能是一个有用的分析物，在预测肾癌患者的生存结局。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
The aim of the present study was to evaluate the clinical significance of the concentration of serum amyloid A (SAA) in patients with renal cell carcinoma (RCC). SAA protein was determined with enzyme-linked immunosorbent assay in serum samples of 55 healthy controls and 98 RCC patients subdivided into groups with localized tumor (N0M0, n = 40), with lymph node metastases (N1M0, n = 13), and distant metastases (M 1, n = 45). SAA concentrations in controls and NOW group of RCC were not different while SAA concentrations were significantly elevated in M1 patients compared to the N1M0 and N0M0 patients. In this respect, SAA provided an accurate detection of distant metastases with the area under the ROC curve of 0.86. SAA was identified as a significant independent factor of survival in RCC patients using the multivariate Cox proportional hazards regression model. SAA could be a useful analyte in predicting the survival outcome of RCC patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.