Theta-Alpha Oscillations Bind the Hippocampus, Prefrontal Cortex, and Striatum during Recollection: Evidence from Simultaneous EEG-fMRI
Theta-Alpha Oscillations Bind the Hippocampus, Prefrontal Cortex, and Striatum during Recollection: Evidence from Simultaneous EEG-fMRI
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DOI：
10.1523/jneurosci.3629-15.2016
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发表时间：
2016-03-23
影响因子：
5.3
通讯作者：
Bunzeck, Nico
中科院分区：
文献类型：
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作者：
Herweg, Nora A.;Apitz, Thore;Bunzeck, Nico
上下文信息的回忆代表了人类识别记忆的核心。它与电生理记录中的Theta（4-8 Hz）功率有关，并且独立地在包括海马和额叶皮质在内的网络中具有大胆的效果。尽管海马在theta范围内通过同步进行新皮质活性的海马概念在理论的回忆模型中很普遍，但支持这种假设的直接证据很少。为了解决我们对内存过程的理解时的明显差距，我们在记住/知道识别任务中将脑电图和fMRI结合在一起。我们可以证明，回忆特异性的theta-α（4-13 Hz）效应与与PFC的海马连通性的增加相关，并且重要的是，纹状体，已反复链接到检索成功的区域。总之，我们的结果提供了令人信服的证据，表明Theta和Alpha范围中的低频振荡提供了一种在成功回忆过程中在功能上结合海马，PFC和纹状体的机制。
Recollection of contextual information represents the core of human recognition memory. It has been associated with theta (4-8 Hz) power in electrophysiological recordings and, independently, with BOLD effects in a network including the hippocampus and frontal cortex. Although the notion of the hippocampus coordinating neocortical activity by synchronization in the theta range is common among theoretical models of recollection, direct evidence supporting this hypothesis is scarce. To address this apparent gap in our understanding of memory processes, we combined EEG and fMRI during a remember/know recognition task. We can show that recollection-specific theta-alpha (4-13 Hz) effects are correlated with increases in hippocampal connectivity with the PFC and, importantly, the striatum, areas that have been linked repeatedly to retrieval success. Together, our results provide compelling evidence that low-frequency oscillations in the theta and alpha range provide a mechanism to functionally bind the hippocampus, PFC, and striatum during successful recollection.