Single-neuron firing cascades underlie global spontaneous brain events.
Single-neuron firing cascades underlie global spontaneous brain events.
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单神经元放电级联是全局自发大脑事件的基础。
DOI：
10.1073/pnas.2105395118
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发表时间：
2021
影响因子：
11.1
通讯作者：
Yang,Yifan
中科院分区：
文献类型：
--
作者：
Liu,Xiao;Leopold,DavidA;Yang,Yifan
休息时的大脑消耗大量能量，表现出高度组织化的自发活动。为了研究这种活动如何在单个神经元中表现出来，我们分析了在静止休息期间从小鼠大脑的多个皮层和皮层下区域记录的约10,000个分离细胞的峰值放电。我们发现，相当大比例（约70%）的神经元的放电符合一个普遍存在的、有时间序列的级联峰，该级联峰与全球事件同步，并在5到10秒的时间尺度上流逝。在整个大脑中，两个混杂的神经元群支持正交级联。这些级联的相对阶段决定了，在每个时刻，由外部视觉刺激引起的反应强度。此外，嵌入这些级联中的单个神经元的尖峰与觉醒的生理指标（包括局部场电位、瞳孔直径和海马体波纹）是时间锁定的。这些发现表明，低频自发活动的大规模协调，通常在脑成像中观察到，与觉醒、感觉处理和记忆有关，是由大脑中连续的、大规模的神经元峰级联支撑的。
The resting brain consumes enormous energy and shows highly organized spontaneous activity. To investigate how this activity is manifest among single neurons, we analyzed spiking discharges of ∼10,000 isolated cells recorded from multiple cortical and subcortical regions of the mouse brain during immobile rest. We found that firing of a significant proportion (∼70%) of neurons conformed to a ubiquitous, temporally sequenced cascade of spiking that was synchronized with global events and elapsed over timescales of 5 to 10 s. Across the brain, two intermixed populations of neurons supported orthogonal cascades. The relative phases of these cascades determined, at each moment, the response magnitude evoked by an external visual stimulus. Furthermore, the spiking of individual neurons embedded in these cascades was time locked to physiological indicators of arousal, including local field potential power, pupil diameter, and hippocampal ripples. These findings demonstrate that the large-scale coordination of low-frequency spontaneous activity, which is commonly observed in brain imaging and linked to arousal, sensory processing, and memory, is underpinned by sequential, large-scale temporal cascades of neuronal spiking across the brain.