Breast cancer histological classification: agreement between the Office for National Statistics and the National Health Service Breast Screening Programme.
Breast cancer histological classification: agreement between the Office for National Statistics and the National Health Service Breast Screening Programme.
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DOI：
10.1186/bcr1352
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Million Women Study Collaborators
中科院分区：
文献类型：
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作者：
Gathani T;Bull D;Green J;Reeves G;Beral V;Million Women Study Collaborators
流行病学研究依赖于中央癌症登记来源提供的及时、准确和完整的数据。在国家一级对这类数据的验证研究有限。为百万妇女研究收集的数据被用来比较国家统计局（ONS）和国家卫生服务乳腺癌筛查计划（NHSBSP）之间的协议水平，在1996年至2001年之间的事件筛查检测乳腺癌组织学的记录。1.3通过NHSBSP招募了100万名年龄在50至64岁之间的妇女进入百万妇女研究队列。ONS和NHSBSP分别通知筛查发现的乳腺癌组织学事件。对ICD-10和ICD-02 ONS代码和NHSBSP组织学数据进行了类似编码，以便在癌症侵袭性和形态学方面进行比较。统计学结局指标为一致率和Kappa统计量。共有5，886例筛查发现的乳腺癌事件可供分析。在ONS和NHSBSP报告的5，886例筛查发现的癌症中，5，684例（96.6%，κ = 0.9）在侵袭性程度方面一致。在5，458例被指定特定形态学代码的癌症中，ONS和NHSBSP在4，922例病例中完全一致（90.2%，κ = 0.8）。ONS和NHSBSP在记录筛查发现的乳腺癌组织学方面具有良好的一致性。根据这些结果，无法评论哪个数据来源更准确或更不准确，尽管差异非常小。
Epidemiological studies rely on data supplied by central cancer registration sources to be timely, accurate and complete. Validation studies of such data at a national level are limited. Data collected for the Million Women Study was used to compare the level of agreement between the Office for National Statistics (ONS) and the National Health Service Breast Screening Programme (NHSBSP) in the recording of incident screen-detected breast cancer histology between 1996 and 2001. 1.3 million women aged 50 to 64 years were recruited into the Million Women Study cohort via the NHSBSP. Incident screen-detected breast cancer histologies were notified separately by the ONS and NHSBSP. ICD-10 and ICD-02 ONS codes and NHSBSP histology data were similarly coded to allow for comparison in terms of cancer invasiveness and morphology. The statistical outcome measures are percentage agreement and the kappa statistic. A total of 5,886 incident screen-detected breast cancers were available for analysis. Of the 5,886 screen-detected cancers reported by the ONS and NHSBSP, 5,684 (96.6%, κ = 0.9) agreed in terms of the degree of invasiveness. Of the 5,458 cancers that had been assigned a specific morphology code, there was exact agreement between the ONS and the NHSBSP in 4,922 cases (90.2%, κ = 0.8). There is an excellent level of agreement between the ONS and NHSBSP in the recording of the histology of screen-detected breast cancer. From these results it is not possible to comment on which source of data is the more or less accurate, although the differences are very small.