Advanced targeted nanomedicine.
Advanced targeted nanomedicine.
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DOI：
10.1016/j.jbiotec.2015.01.009
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发表时间：
2015-05-20
影响因子：
4.1
通讯作者：
Andreev OA
中科院分区：
文献类型：
--
作者：
Pereira MC;Reshetnyak YK;Andreev OA
靶向给药是药物制剂和给药系统的主要研究课题。随着纳米医学的出现，创造了纳米尺度的治疗和诊断方法，将靶向能力嵌入这些新系统以使其有用仍然是至关重要的。在这里，我们讨论了各种靶向治疗和诊断的纳米材料，在寻找更通用的方法来靶向病变组织的交付方法。许多疾病都伴有缺氧和酸中毒。用pH低插入肽（pHLIP）涂覆纳米颗粒增加了靶向酸性病变组织的效率。它已经显示出有希望的结果，以创造未来的nanotheranostics为癌症和其他疾病是占主导地位的在当今世界。
Targeted drug delivery has been the major topic in drug formulation and delivery. As nanomedicine emerges to create nano scale therapeutics and diagnostics, it is still essential to embed targeting capability to these novel systems to make them useful. Here we discuss various targeting approaches for delivery of therapeutic and diagnostic nano materials in view of search for more universal methods to target diseased tissues. Many diseases are accompanied with hypoxia and acidosis. Coating nanoparticles with pH Low Insertion Peptides (pHLIPs) increases efficiency of targeting acidic diseased tissues. It has been showing promising results to create future nanotheranostics for cancer and other diseases which are dominating in the present world.