Compartmentation of glutathione: Implications for the study of toxicity and disease
Compartmentation of glutathione: Implications for the study of toxicity and disease
复制标题
DOI：
10.1006/taap.1996.0191
复制
发表时间：
1996-09-01
影响因子：
3.8
通讯作者：
Lauterburg, BH
中科院分区：
文献类型：
--
作者：
Smith, CV;Jones, DP;Lauterburg, BH
几十年来，人们已经认识到谷胱甘肽（GSH）在生物保护机制和关键生理功能中发挥着许多作用，缀合物、二硫化物和其他谷胱甘肽衍生产品也被研究为有毒物质的化学性质或关键代谢物的特定特性的生物标志物，这些研究对于描述近端毒物与目标生物分子相互作用的性质至关重要。尽管有大量的证据表明谷胱甘肽的消耗和/或氧化与各种各样的人类和实验毒性有关，但对这些研究的批判性检查经常表明，损伤不仅仅与谷胱甘肽状态有关，谷胱甘肽在几个水平上被区隔化，这种区隔化似乎对谷胱甘肽消耗或氧化与损伤发生之间的关系具有相当大的影响。虽然通常是从不同的细胞内池的角度来看待区隔作用，但细胞外谷胱甘肽在功能重要池中的重要性正在得到认识。随着影响细胞内池与细胞外池相互作用的因素被描述，人类研究可以更精确和实用地设计和解释。(C) 1996学术出版社，Inc.
The fact that glutathione (GSH) plays many roles in biological protective mechanisms and critical physiological functions has been recognized for decades, Conjugates, disulfides, and other glutathione-derived products also have been studied as biomarkers of the chemical natures or specific identities of key metabolites of toxic agents and such studies have been crucial in the delineation of the nature of the interactions of proximal toxicants with target biomolecules. Despite the extensive evidence implicating the depletion and/or oxidation of glutathione in a wide variety of human and experimental toxicities, critical examination of such studies frequently reveals that injury is not simply related to glutathione status, GSH is compartmentalized at several levels and this compartmentation appears to exert considerable influence on the relationships between glutathione depletion or oxidation and the onset of injury, Although compartmentation is usually viewed from the perspective of different intracellular pools, the significance of extracellular glutathione in functionally important pools is gaining recognition, As the factors affecting the interactions of intracellular pools with extracellular pools are delineated, studies in humans can be designed and interpreted with greater precision and utility. (C) 1996 Academic Press, Inc.