Moving targets: recognition of alkyl groups.
Moving targets: recognition of alkyl groups.
复制标题
DOI：
10.1002/chem.200600338
复制
发表时间：
2006-08
期刊：
影响因子：
--
通讯作者：
M. Schramm;J. Rebek
中科院分区：
文献类型：
--
作者：
M. Schramm;J. Rebek
当烷基链与天然和合成的疏水受体结合时，可以采用看似不寻常的构象，如螺旋。这种可塑性使烷烃能够呈现出与受体空间一致的形状，并适当地填充该空间。我们在这里描述了使用空腔体和胶囊作为工具，揭示了参与碳氢化合物分子识别的力量。利用核磁共振波谱的研究揭示了通过前所未有的烷烃扭曲如何在溶液中最大化吸引相互作用和疏溶剂力，并暗示了新一代纳米级机械设备。
Alkyl chains can adopt seemingly unusual conformations, such as helices, when bound to natural and synthetic hydrophobic receptors. This plasticity allows the alkanes to assume shapes that are congruent to the receptor's space and fill that space properly. We describe here the use of cavitands and capsules as tools that expose the forces involved in the molecular recognition of hydrocarbons. Studies using NMR spectroscopy reveal how attractive interactions and solvophobic forces are maximized in solution through unprecedented contortions of alkanes and hint at a new generation of nanoscale mechanical devices.