Continuous Photo-Oxidation in a Vortex Reactor: Efficient Operations Using Air Drawn from the Laboratory.
Continuous Photo-Oxidation in a Vortex Reactor: Efficient Operations Using Air Drawn from the Laboratory.
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DOI：
10.1021/acs.oprd.7b00153
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发表时间：
2017-07-21
影响因子：
3.4
通讯作者：
George MW
中科院分区：
文献类型：
--
作者：
Lee DS;Amara Z;Clark CA;Xu Z;Kakimpa B;Morvan HP;Pickering SJ;Poliakoff M;George MW
我们报告了涡旋反应器的构造和使用，该反应器使用快速旋转的圆柱体来产生泰勒涡流以进行连续流热和光化学反应。该反应器设计为在产生涡流所需的条件下运行。涡流的流动模式已使用计算流体动力学来表示，并且通过观察反应器内的气泡流可以轻松地可视化涡流的存在。这种方法对于添加气体的反应具有一定的优势。对于与氧气的反应，反应器提供了传统装置的替代方案，因为它可以有效地从实验室吸入空气，而无需专门用氧气加压。涡流产生的快速混合能够实现气相和液相之间的快速传质，从而实现气体的高效溶解。该反应器已应用于多种涉及单线态氧（1O2）的光化学反应，包括α-萜品烯和糠醇的光氧化以及苯基硼酸的光脱硼。气缸的转速被证明是反应效率的关键，在操作中我们发现在4000转/分钟时空气的吸入量最高。该反应器还成功应用于青蒿素的合成，青蒿素是一种有效的抗疟化合物；这种由二氢青蒿酸进行的三步合成，包括与 1O2 的申克烯反应、与 H+ 的 Hock 裂解以及与三线态氧 (3O2) 的氧化环化级联，是在涡流反应器中作为单一过程进行的。
We report the construction and use of a vortex reactor which uses a rapidly rotating cylinder to generate Taylor vortices for continuous flow thermal and photochemical reactions. The reactor is designed to operate under conditions required for vortex generation. The flow pattern of the vortices has been represented using computational fluid dynamics, and the presence of the vortices can be easily visualized by observing streams of bubbles within the reactor. This approach presents certain advantages for reactions with added gases. For reactions with oxygen, the reactor offers an alternative to traditional setups as it efficiently draws in air from the lab without the need specifically to pressurize with oxygen. The rapid mixing generated by the vortices enables rapid mass transfer between the gas and the liquid phases allowing for a high efficiency dissolution of gases. The reactor has been applied to several photochemical reactions involving singlet oxygen (1O2) including the photo-oxidations of α-terpinene and furfuryl alcohol and the photodeborylation of phenyl boronic acid. The rotation speed of the cylinder proved to be key for reaction efficiency, and in the operation we found that the uptake of air was highest at 4000 rpm. The reactor has also been successfully applied to the synthesis of artemisinin, a potent antimalarial compound; and this three-step synthesis involving a Schenk-ene reaction with 1O2, Hock cleavage with H+, and an oxidative cyclization cascade with triplet oxygen (3O2), from dihydroartemisinic acid was carried out as a single process in the vortex reactor.
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影响因子：
3.7
作者：
Atkhen, K;Fontaine, J;Wesfreid, JE
通讯作者：
Wesfreid, JE
影响因子：
4.9
作者：
Bourne, Richard A.;Han, Xue;George, Michael W.
通讯作者：
George, Michael W.
DOI：
10.1016/j.expthermflusci.2003.06.003
发表时间：
2004-04-01
影响因子：
3.2
作者：
Dluska, E;Wronski, S;Ryszczuk, T
通讯作者：
Ryszczuk, T
影响因子：
4.7
作者：
Dutta, PK;Ray, AK
通讯作者：
Ray, AK
影响因子：
9.8
作者：
Hall, Jessica F. B.;Bourne, Richard A.;George, Michael W.
通讯作者：
George, Michael W.