Prevalence of vulvovaginal candidiasis and susceptibility to fluconazole in women
Prevalence of vulvovaginal candidiasis and susceptibility to fluconazole in women
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DOI：
10.1067/mob.2002.125897
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发表时间：
2002-09-01
影响因子：
9.8
通讯作者：
Nelis, HJ
中科院分区：
文献类型：
--
作者：
Bauters, TGM;Dhont, MA;Nelis, HJ
目的：本研究的目的是确定阴道念珠菌定植的患病率与使用的快速检测方法，检查阴道念珠菌病的决定因素，并评估对fluconazol.Study Design的敏感性：阴道拭子收集在妇产科的门诊部的女性。一个分化与阳性和阴性氢氧化钾testing.Results：六百一十二名妇女被招募，其中39名妇女（6.3%）有临床念珠菌病患者之间。酵母菌定植率为20.1%。白色念珠菌最常见（68.3%），其次是光滑念珠菌（16.3%）和近平滑念珠菌（8.9%）。临床念珠菌感染与雌激素的浸润状态呈正相关。用美国临床实验室标准化委员会的方法对氟康唑进行体外药敏试验，结果显示21.1%的分离株耐药。高雌激素血症与念珠菌外阴阴道定植增加有关。令人惊讶的是，根据国家临床实验室标准委员会的方法，21%的分离株对氟康唑耐药。
OBJECTIVE: The purpose of this study was to determine the prevalence of vaginal colonization by Candida with the use of a rapid detection method, to examine the determinants of vaginal candidiasis, and to evaluate susceptibility for fluconazole.STUDY DESIGN: Vaginal swabs were collected from unselected women at the outpatient clinic of the Department of Obstetrics and Gynecology. A differentiation was made between patients with a positive and a negative potassium hydroxide examination.RESULTS: Six hundred twelve women were recruited, of whom 39 women (6.3%) had clinical candidiasis. The overall rate of yeast colonization was 20.1%. Candida albicans was isolated most frequently(68.3%), followed by C glabrata (16.3%) and C parapsilosis (8.9%). Clinical candidiasis was related positively with the state of estrogen impregnation. In vitro susceptibility testing by the National Committee for Clinical Laboratory Standards method for fluconazole revealed that 21.1% of the isolates were resistant.CONCLUSION: More than 20% of the unselected women were colonized with Candida species. Hyperestrogenemia was associated with an increased vulvovaginal colonization by Candida. Surprisingly, 21% of the isolates was resistant to fluconazole, according to the National Committee for Clinical Laboratory Standards method.