Age and ovarian reserve are distinct predictive factors of cycle outcome in low responders
Age and ovarian reserve are distinct predictive factors of cycle outcome in low responders
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DOI：
10.1016/s1472-6483(10)60808-5
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发表时间：
2005-01-01
影响因子：
4
通讯作者：
Galey-Fontaine, J
中科院分区：
文献类型：
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作者：
Galey-Fontaine, J
年龄和卵巢储备在预测体外受精结果中的各自作用似乎并不相等，因为尽管卵巢招募较低，但最年轻的女性似乎保留了高妊娠率。本研究的目的是根据卵巢对刺激反应低的患者的年龄和卵巢储备来分析体外受精/卵胞浆内单精子注射（ICSI）手术的结果。通过低反应选择163个IVF/ICSI周期进行分析。体外受精结果因女性年龄而异，截止值为36岁。在移植胚胎数量相同的情况下，年轻患者的妊娠率（PR）为14.6%，而老年患者的PR为4.9% （P < 0.04）。FSH升高经常与不良的周期结果相关。而FSH正常时，< 36岁女性的PR（23.8%）明显高于大于等于36岁女性（6.5%）（P < 0.05）。本研究表明卵巢反应低的女性辅助生殖的结果主要取决于卵巢状态。在FSH正常的患者中，年龄的负面影响是相关的。因此，即使卵巢对刺激的反应较低，年龄< 36岁且卵泡刺激素正常的患者也应进行卵母细胞回收。
The respective roles of age and ovarian reserve in predicting IVF outcome do not seem to be equivalent, as a high pregnancy rate seems to be preserved in the youngest women, despite low ovarian recruitment. The purpose of this study was to analyse the outcome of IVF/intracytoplasmic sperm injection (ICSI) procedures according to both age and ovarian reserve of patients with a low ovarian response to stimulation. A total of 163 IVF/ICSI cycles selected by a low response were analysed. The IVF outcome differed according to the women's age, with a cut-off value at 36 years. While the number of transferred embryos was similar, the pregnancy rate (PR) was 14.6% in younger patients but 4.9% (P < 0.04) in older ones. An elevated FSH was constantly associated with a poor cycle Outcome. In contrast, when the FSH was normal, PR was significantly higher (P < 0.05) in women aged < 36 (23.8%) than in women aged greater than or equal to 36 (6.5%). This study shows that assisted reproduction outcome in women with a low ovarian response is primarily dependent on the ovarian status. The negative influence of age is relevant in patients with normal FSH. Therefore, even if the ovarian response to stimulation is low, patients aged < 36 years with a normal FSH should proceed to oocyte retrieval.