Current Progress on Understanding MicroRNAs in Glioblastoma Multiforme.
Current Progress on Understanding MicroRNAs in Glioblastoma Multiforme.
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DOI：
10.1177/1947601912448068
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Moy, Fred
中科院分区：
文献类型：
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作者：
Karsy, Michael;Arslan, Erol;Moy, Fred
多形性胶质母细胞瘤（GBM）是一种侵袭性IV级星形细胞瘤，尽管采用目前的治疗方式，其中位生存率为1年。对神经胶质瘤形成过程中涉及的大量遗传畸变和信号通路以及异质临床病理表现的透彻理解仍然难以捉摸。最近发现的microRNAs （miRs）及其同时调节多个下游基因的能力可能在解释GBM形成的复杂机制中发挥关键作用。miRs是19到25个核苷酸的非蛋白质编码小RNA分子，参与抑制mRNA翻译。本文将总结和讨论miRs在GBM中的最新发现，包括下游靶点、功能效应和治疗潜力。具体讨论的miRs包括miR-7、miR-9/miR-9*、miR-10a/miR-10a*/miR-10b、miR-15b、miR-17-92、miR-21、miR-26a、miR-34a、miR-93、miR-101、miR-124、miR-125a、miR-125b、miR-128、miR-137、miR-146b-5p、miR-153、miR-181a/miR-181b、miR-196a/miR-196b、miR-218、miR-221/miR-222、miR-296、miR-302-367、miR-326、miR-381、miR-451和mir -7a。除了基因调控作用外，miRs还显示出重要的诊断、预后和治疗潜力。这些小分子可能有助于了解GBM和开发新的治疗方案。
Glioblastoma multiforme (GBM) is an aggressive grade IV astrocytoma with a 1-year median survival rate despite current treatment modalities. A thorough understanding of the vast genetic aberrations and signaling pathways involved in gliomagenesis as well as heterogeneous clinicopathological presentation remains elusive. The recent discovery of microRNAs (miRs) and their capability of simultaneously regulating multiple downstream genes may play a key role in explaining the complex mechanisms underlying GBM formation. miRs are 19 to 25 nucleotide non-protein-coding small RNA molecules involved in the suppression of mRNA translation. This review will summarize and discuss the most recent findings regarding miRs in GBM including downstream targets, functional effects, and therapeutic potentials. Specifically discussed miRs include miR-7, miR-9/miR-9*, miR-10a/miR-10a*/miR-10b, miR-15b, miR-17-92, miR-21, miR-26a, miR-34a, miR-93, miR-101, miR-124, miR-125a, miR-125b, miR-128, miR-137, miR-146b-5p, miR-153, miR-181a/miR-181b, miR-196a/miR-196b, miR-218, miR-221/miR-222, miR-296, miR-302-367, miR-326, miR-381, miR-451, and let-7a. In addition to gene regulatory roles, miRs have demonstrated significant diagnostic, prognostic, and therapeutic potential. These small molecules may both help in the understanding of GBM and in developing new therapeutic options.