PEP and TasP Awareness among Italian MSM, PLWHA, and High-Risk Heterosexuals and Demographic, Behavioral, and Social Correlates.
PEP and TasP Awareness among Italian MSM, PLWHA, and High-Risk Heterosexuals and Demographic, Behavioral, and Social Correlates.
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DOI：
10.1371/journal.pone.0157339
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Oldrini M
中科院分区：
文献类型：
--
作者：
Prati G;Zani B;Pietrantoni L;Scudiero D;Perone P;Cosmaro L;Cerioli A;Oldrini M
暴露后预防（PEP）已被提议作为在某些高风险暴露后预防艾滋病毒感染的策略，并且治疗即预防（TasP）也被提倡作为减少艾滋病毒性传播的手段。本研究的目的是调查意大利 PEP 和 TasP 意识的流行情况及其人口、行为和社会相关性。我们对 1,028 名高危异性恋男性和女性、1,874 名非 HIV 阳性 MSM（男男性行为者）和 694 名艾滋病毒/艾滋病感染者 (PLWHA) 进行了横断面调查。大多数参与者了解 PEP，但不了解 TasP。与 PLWHA 相比，MSM 对 PEP 和 TasP 的了解较少，但比高危异性恋参与者对 PEP 和 TasP 的了解更多。与 PEP 和 TasP 意识最一致的变量是与 HIV/AIDS 组织的接触、HIV 检测和 HIV 耻辱。在高危异性恋参与者中发现无保护性交与 PEP 和 TasP 意识之间存在正相关关系，而这种相关性在 MSM 和 PLWHA 中并不显着。由于目前推荐 PEP 和 TasP，因此需要有效的教育和传播策略来提高有关 PEP 和 TasP 的知识水平。
Post-exposure prophylaxis (PEP) has been proposed as a strategy to prevent the acquisition of HIV infection after certain high-risk exposures, and treatment as prevention (TasP) is also being advocated as a means to reduce sexual transmission of HIV. The aim of this study was to investigate the prevalence of PEP and TasP awareness and their demographic, behavioral, and social correlates in Italy. We conducted a cross-sectional survey of 1,028 high-risk heterosexual men and women, 1,874 non-HIV positive MSM (men who have sex with men), and 694 people living with HIV/AIDS (PLWHA). The majority of the participants was aware of PEP and unaware of TasP. MSM were less knowledgeable about PEP and TasP than were PLWHA and more knowledgeable about PEP and TasP than were high-risk heterosexual participants. The variables most consistently associated with PEP and TasP awareness were contact with HIV/AIDS organizations, HIV testing, and HIV stigma. A positive relationship between unprotected sexual intercourse and PEP and TasP awareness was found among high risk heterosexual participants, while this association was not significant among MSM and PLWHA. Because PEP and TasP are currently recommended, effective educational and dissemination strategies are needed to increase the level of knowledge about PEP and TasP.