3-D OCT angiographic evidence of Anti-VEGF therapeutic effects on retinal capillary hemangioma.
3-D OCT angiographic evidence of Anti-VEGF therapeutic effects on retinal capillary hemangioma.
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DOI：
10.1016/j.ajoc.2022.101394
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发表时间：
2022-03
影响因子：
--
通讯作者：
Rosen RB
中科院分区：
文献类型：
--
作者：
Otero-Marquez O;Chui TY;Pinhas A;Castanos Toral MV;Zhou DB;Migacz J;Rosen RB
除了标准成像方式外，还使用临床 OCT 血管造影 (OCT-A) 报告玻璃体内抗血管内皮生长因子 (VEGF) 治疗对视网膜毛细血管瘤 (RCH) 的影响。一名 25 岁男性 Von Hippel-Lindau (VHL) 病患者有双侧 RCH 病史。右眼看不到任何景象。左眼检查发现有 6 个周边 RCH，其中最小的位于黄斑颞侧，有活跃渗出。这种 RCH 被认为是累及中央凹的黄斑囊样水肿 (CME) 的根源，因此也是视力下降的根源。 14 个月内注射 11 次 1.25 毫克贝伐珠单抗 EA。治疗前和治疗后 RCH 处的 OCT-A 比较显示 CME 减少和 RCH 消退。抗 VEGF 治疗似乎可以稳定视力并使 RCH 部分消退。当视力受到威胁时，它提供了一个安全的选择。 OCT 和 OCT-A 能够记录抗血管生成治疗对 RCH 的影响。 OCT-A 的 3D 渲染增强了识别 RCH 结构和功能变化的灵敏度，这可能有助于监测治疗反应。
To report the impact of intravitreal anti–vascular endothelial growth factor (VEGF) therapy on a retinal capillary hemangioma (RCH) using clinical OCT angiography (OCT-A) in addition to standard imaging modalities. A 25-year-old male patient with Von Hippel-Lindau (VHL) disease presented with a history of bilateral RCH. No view was present in the right eye. Examination of the left eye revealed six peripheral RCH, the smallest of which was temporal to the macula with active exudation. This RCH was thought to be the source of cystoid macular edema (CME) involving the fovea, and therefore, the source of vision decline. 11 injections of 1.25mg of Bevacizumab EA across 14-month was given. Comparison of the pre- and post-treatment OCT-A at the temporal RCH showed a reduction of CME and regression of RCH. Anti-VEGF therapy appeared to stabilize the visual acuity and produce partial regression of RCH. It offers a safe option when visual acuity is threatened. OCT and OCT-A have the ability to document the impact of antiangiogenic therapy on RCH. 3D renderings of OCT-A offer enhanced sensitivity to recognition of structural and functional changes of RCH which may prove useful for monitoring treatment response.