Body composition is distinctly altered in Turner syndrome: relations to glucose metabolism, circulating adipokines, and endothelial adhesion molecules
Body composition is distinctly altered in Turner syndrome: relations to glucose metabolism, circulating adipokines, and endothelial adhesion molecules
复制标题
DOI：
10.1530/eje.1.02267
复制
发表时间：
2006-10-01
影响因子：
5.8
通讯作者：
Christiansen, Jens Sandahl
中科院分区：
文献类型：
--
作者：
Gravholt, Claus Hojbjerg;Hjerrild, Britta Eilersen;Christiansen, Jens Sandahl
背景资料：Turner综合征（TS）患者的身体成分随着最终身高的降低而改变：人体测量和骨量明显改变。目的：描述TS患者脂肪和肌肉质量的总体和区域分布以及与葡萄糖代谢、性激素、IGF、炎症和血管功能标志物的关系。材料和方法：54名TS女性（平均年龄42.5 ± 9.7岁）和年龄匹配的对照组（n=55）进行了双能X线吸收扫描检查，确定区域身体成分和内脏脂肪和骨骼肌质量的估计。我们确定最大摄氧量，并使用问卷调查评估体力活动。我们检测了血清脂联素、生长激素释放肽、胰岛素样生长因子-I、胰岛素样生长因子结合蛋白-3（IGFBP-3）、雌二醇、睾酮、性激素结合球蛋白（SHBG）、胰岛素、葡萄糖、细胞因子、血管细胞粘附分子-I和细胞间细胞粘附分子-I。估计胰岛素敏感性。结果：TS组的总瘦体重（LBM）较低，而体重指数（BMI）和总脂肪量（FM）较高。我们发现内脏FM增加，躯干LBM、四肢LBM和骨骼肌质量减少。最大摄氧量和体力活动显着降低TS，因为大多数激素水平，除了增加瘦素，在多元线性回归模型，状态（即TS或控制）是一个一致的贡献variable.Conclusion：深刻的变化是存在于TS的身体成分，增加FM，和骨骼肌质量下降。循环激素、最大摄氧量和胰岛素敏感性影响身体成分。内脏脂肪的积累预示着更高的胰岛素抵抗综合征风险。
Background: Body composition in Turner syndrome (TS) is altered with final height of TS decreased: anthropometry and bone mass distinctly changed.Aim: To describe total and regional distribution of fat and muscle mass in TS and the relation to measures of glucose metabolism, sex hormones, IGFs, and markers of inflammation and vascular function.Material and methods: Fifty-four women with TS (mean age, 42.5 +/- 9.7 years) and an age-matched group of controls (n=55) were examined by dual-energy X-ray absorptiometry scans with determination of regional body composition and estimation of visceral fat and skeletal muscle mass. We determined maximal oxygen uptake and assessed physical activity using a questionnaire. We measured serum adiponectin, ghrelin, IGF-I, IGF-binding protein-3 (IGFBP-3), estradiol, testosterone, sex hormone-binding globulin (SHBG), insulin, glucose, cytokines, vascular cell adhesion molecule-I, and intercellular cell adhesion molecule-I. Insulin sensitivity was estimated. Multiple linear regression models were used to examine the relationships between variables.Results: TS had lower total lean body mass (LBM), while body mass index (BMI) and total fat mass (FM) were increased. We found increased visceral FM, and decreased trunk LBM, appendicular LBM, and skeletal muscle mass. VO2max and physical activity were significantly lower in TS, as were most hormone levels, except increased leptin, In multiple linear regression models, status (i.e. TS or control) was a consistent contributing variable.Conclusion: Profound changes are present in body composition in TS, with increased FM, and decreased skeletal muscle mass. Circulating hormones, VO2max, and insulin sensitivity influence body composition. The accumulation of visceral fat would predict a higher risk of development of the insulin resistance syndrome.