The NQO1 rs1800566 Polymorphism and Risk of Bladder Cancer: Evidence from 6,169 Subjects
The NQO1 rs1800566 Polymorphism and Risk of Bladder Cancer: Evidence from 6,169 Subjects
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DOI：
10.7314/apjcp.2012.13.12.6343
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发表时间：
2012-01-01
影响因子：
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通讯作者：
Feng, Chang-Long
中科院分区：
文献类型：
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作者：
Guo, Zhan-Jing;Feng, Chang-Long
目的：NAD(P)H：醌氧化还原酶1 (NQO1) rs1800566多态性导致脯氨酸-丝氨酸氨基酸和酶活性改变，与膀胱癌风险有关，但个别发表的研究结果不一致。因此，我们在此进行了荟萃分析，以总结可能的关联。方法：系统检索PubMed、EMBASE和万方数据库截至2012年8月27日的文献，对检索到的文献进行筛选。分析纯合子对比（TT vs. CC）、加性模型（T vs. C）、显性模型（TT+CT vs. CC）和隐性模型（TT vs. CC+CT）的粗优势比（or）和95%置信区间（ci），使用固定效应或随机效应模型评估相关性。结果：我们确定了12项病例对照研究，包括3041例病例和3128例对照。在加性模型中，NQO1 rs1800566基因多态性与膀胱癌风险存在显著相关性（OR = 1.15, 95% CI = 1.01-1.30, p = 0.030）。此外，在按种族分层的亚组分析中，亚洲人观察到显著相关性（T与C的OR = 1.26, 95% CI = 1.08-1.47, p = 0.003； TT与CC的OR = 1.68, 95% CI = 1.21-2.32, p = 0.002； TT与CT+CC的OR = 1.50, 95% CI = 1.13-1.98, p = 0.005），但在白种人中没有。结论：NQO1 rs1800566基因多态性可能与膀胱癌的发生有关，尤其是在亚洲人群中。
Objective: The NAD(P)H: quinone oxidoreductase 1 (NQO1) rs1800566 polymorphism, leading to proline-toserine amino-acid and enzyme activity changes, has been implicated in bladder cancer risk, but individually published studies showed inconsistent results. We therefore here conducted a meta-analysis to summarize the possible association. Methods: A systematic literature search up to August 27, 2012 was carried out in PubMed, EMBASE and Wanfang databases, and the references of retrieved articles were screened. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analyzed for homozygote contrast (TT vs. CC), additive model (T vs. C), dominant model (TT+CT vs. CC), and recessive model (TT vs. CC+CT) to assess the association using fixed- or random-effect models. Results: We identified 12 case-control studies including 3,041 cases and 3,128 controls for the present meta-analysis. Significant association between NQO1 rs1800566 genetic polymorphism and risk of bladder cancer was observed in the additive model (OR = 1.15, 95% CI = 1.01-1.30, p = 0.030). Moreover, in the subgroup analysis stratified by ethnicity, significant associations were observed in Asians (OR = 1.26, 95% CI = 1.08-1.47, p = 0.003 for T vs. C; OR = 1.68, 95% CI = 1.21-2.32, p = 0.002 for TT vs. CC; OR = 1.50, 95% CI = 1.13-1.98, p = 0.005 for TT vs. CT+CC) but not in Caucasians. Conclusions: The results suggest that NQO1 rs1800566 genetic polymorphism may contribute to bladder cancer development, especially in Asians.