Bronchial hyperreactivity in response to inhalation of ultrasonically nebulised solutions of distilled water and saline.
Bronchial hyperreactivity in response to inhalation of ultrasonically nebulised solutions of distilled water and saline.
复制标题
吸入超声雾化的蒸馏水和盐水溶液后出现支气管高反应性。
DOI：
10.1136/bmj.284.6313.417-a
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
R. Altounyan
中科院分区：
文献类型：
--
作者：
R. Schoeffel;S. Anderson;R. Altounyan
为评价非特异性支气管反应性，对10例哮喘患者和9例正常人分别吸入蒸馏水和低渗（0.3%）、等渗（0.9%）和高渗（27%，3.6%）生理盐水超声雾化液进行了观察。记录呼气通气量和一秒用力呼气量（FEV）的最大下降百分比。通过测量诱导FEV从激发前值下降20%所需的通气量，确定对吸入溶液的敏感性。在哮喘受试者中，低渗和高渗溶液而不是等渗溶液引起FEV显著下降。正常受试者没有反应，无论是蒸馏水或3 - 6%的盐水，唯一的解决方案，他们受到挑战。用于该挑战的方法是快速、简单和廉价的，并且提供了诊断非免疫介导的支气管高反应性的新手段。摘要在一组白色类风湿性关节炎患者、来自印度次大陆的类似患者和相应的对照组中测定了HLA-DR抗原的流行率。在白色患者中发现风湿性关节炎与DR 4高度相关，但在印度患者中与DR 1高度相关。这些结果提出了这样的可能性，即DR抗原本身在增加对类风湿性关节炎的易感性中不起作用，但增加易感性的位点可能与DR位点密切相关。
To assess non-specific bronchial reactivity the effect of inhaling ultrasonically nebulised solutions of distilled water and hypotonic (0 3%), isotonic (0 9%), and hyper- tonic (27%, 3 6%) saline was investigated in 10 asthmatic patients and nine normal subjects. Expired ventilation and the maximum percentage fall in forced expiratory volume in one second (FEV,) were recorded. The sensi- tivity to the inhaled solutions was determined by measuring the ventilation required to induce a fall in FEV, of 20% from the prechallenge value. Hypotonic and hyper- tonic but not isotonic solutions caused a significant fall in FEV, in the asthmatic subjects. Normal subjects showed no response to either distilled water or 3 6% saline, the only solutions with which they were challenged. The method used for this challenge is rapid, simple, and inexpensive and provides a new means of diagnosing non-immunologically mediated bronchial hyperreac- tivity. Abstract The prevalence of HLA-DR antigens was determined in a group of white patients with rheumatoid arthritis, similar patients originating from the Indian subcontinent, and corresponding controls. Rheumatoid arthritis was found to be highly associated with DR4 in the white patients but with DR1 in the Indian patients. These results raise the possibility that the DR antigens themselves do not play a part in increasing susceptibility to rheumatoid arthritis, but the locus for increased susceptibility is probably closely linked to the DR locus.