The effect of energy-protein supplementation on weight, body composition and handgrip strength among pulmonary tuberculosis HIV-co-infected patients: randomised controlled trial in Mwanza, Tanzania
The effect of energy-protein supplementation on weight, body composition and handgrip strength among pulmonary tuberculosis HIV-co-infected patients: randomised controlled trial in Mwanza, Tanzania
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DOI：
10.1017/s0007114511002832
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发表时间：
2012-01-28
影响因子：
3.6
通讯作者：
Friis, Henrik
中科院分区：
文献类型：
--
作者：
PrayGod, George;Range, Nyagosya;Friis, Henrik
营养不良在涂阳肺结核（PTB +）患者中很常见。微量营养素的补充可能会改善治疗结果，但目前尚不清楚额外的能量蛋白质是否有益。本研究旨在评估能量蛋白补充对结核病治疗期间高微量营养素摄入背景下体重、身体组成和握力的影响。共377例合并HIV感染的PTB +患者在TB治疗期间每天随机分配1块或6块饼干，持续60 d，在基线和2个月和5个月时评估体重、手臂脂肪面积、手臂肌肉面积和握力。在2个月时对任何结果没有影响，但能量蛋白质补充与5个月时1.3 (95% CI -0.1, 2.8) kg的手握力边际显著增加相关。然而，2个月后，补充能量蛋白导致分化群集4 （CD4）计数>= 350细胞/ μ l的患者体重增加1.9 kg (95% CI 0.1, 3.7)，但CD4计数低的患者没有（-0.2 kg; 95% CI - 1.3, 0.8， p -相互作用= 0.03）。同样，在5个月时，补充能量蛋白导致CD4计数患者的握力增加2.3 kg （95% CI 0.6, 4.1）
Undernutrition is common among smear-positive pulmonary tuberculosis (PTB +) patients. Micronutrient supplementation may improve treatment Outcomes, but it is unclear whether additional energy protein would be beneficial. The present study aimed to assess the effect of energy-protein supplementation on weight, body composition and handgrip strength against a background of high micronutrient intake during tuberculosis (TB) treatment. A total of 377 PTB + patients co-infected with HIV were randomly allocated One or six biscuits daily for 60 d during TB treatment, Weight, arm fat area, arm muscle area and handgrip strength were assessed at baseline and 2 and 5 months. There were no effects on any outcome at 2 months, but energy-protein supplementation was associated with a 1.3 (95% CI -0.1, 2.8) kg marginally significant gain in handgrip strength at 5 months. However, after 2 months, energy-protein supplementation led to a weight gain of 1.9 (95% CI 0.1, 3.7) kg among patients with cluster of differentiation 4 (CD4) counts >= 350 cells/mu l, but not among patients with low CD4 counts (-0.2 kg; 95% CI - 1.3, 0.8, P-interaction = 0.03). Similarly, at 5 months, energy-protein supplementation led to a 2.3 (95% CI 0.6, 4.1) kg higher handgrip strength gain among patients with CD4 counts