Sarcomere-associated cytoskeletal lattices in striated muscle. Review and hypothesis.
Sarcomere-associated cytoskeletal lattices in striated muscle. Review and hypothesis.
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横纹肌中肌节相关的细胞骨架晶格。
DOI：
10.1007/978-1-4757-4723-2_10
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Wang,K
中科院分区：
文献类型：
--
作者：
Wang,K
肌节是横纹肌细胞的基本收缩单位，被广泛认为是由两组不连续且不可伸展的平行和交错的蛋白质细丝组成的。这种双丝肌节模型为强大的肌肉收缩滑动细丝理论提供了结构基础。然而，最近的结构、生化和免疫细胞化学研究清楚地表明，肌节除了粗丝和细丝组合外，还有额外的丝状成分。本章的目的是概述和发展关键证据，这些证据导致了肌节包含两组不同的细胞骨架细丝的概念，这些细丝是连续的和可延伸的。一组细胞骨架细丝与粗丝和细丝共存于肌节内(内壁晶格)；另一组是包裹每个肌节并相互连接其他细胞器的中间细丝的广泛网络(内囊晶格)。
The sarcomere, the basic contractile unit of striated muscle cells, is widely accepted as being constructed of two sets of parallel and interdigitated protein filaments that are discontinuous and inextensible. This two-filament sarcomere model provides a structural basis for the powerful sliding-filament theory of muscle contraction. Recent structural, biochemical, and immunocytochemical studies, however, have clearly indicated that the sarcomere has additional filamentous constituents besides thick and thin filament assemblies. The pur pose of this chapter is to outline and develop key evidence that has led to the notion that the sarcomere contains two sets of distinct cytoskeletal filaments that are continuous and extensible. One set of cytoskeletal filaments coexists with thick and thin filaments within the sarcomere (an endosarcomeric lattice); the other set is an extensive network of intermediate filaments enveloping each sarcomere and interlinking other cellular organelles (an e~ osarcomeric lattice).