Carcinoma cuniculatum mimicking leukoplakia of the mandibular gingiva
Carcinoma cuniculatum mimicking leukoplakia of the mandibular gingiva
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DOI：
10.1016/j.anl.2011.06.004
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发表时间：
2012-06-01
影响因子：
1.7
通讯作者：
Suzuki, Hiroyoshi
中科院分区：
文献类型：
--
作者：
Suzuki, Jun;Hashimoto, Sho;Suzuki, Hiroyoshi
楔状癌（CC）是一种罕见的变异低度鳞状细胞癌（SCC），发生在口腔是相当罕见的。CC具有类似疣状癌的乳头状角化表面，但CC具有侵袭性局部浸润的倾向，尤其是侵入骨。因此，CC可能很难通过手术移除。一位68岁男性提出了一个案件的CC模仿疣状白斑在下颌牙龈。反复活检未发现恶性肿瘤。局部切除，组织学检查显示存在分化良好的SCC。进行了额外的半下颌骨切除术，最终组织学诊断为CC。在14个月的随访检查中发现局部复发。多西他赛化疗无效，他死于吸入性肺炎。口腔CC是一种罕见的实体，诊断很难建立。误诊可能导致切除不充分和局部复发。由于有局部侵犯的倾向，在安全范围内完全切除是必要的。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Carcinoma cuniculatum (CC) is a rare variant of low-grade squamous cell carcinoma (SCC), and occurrence in the oral cavity is quite unusual. CC has a papillomatous keratinized surface like verrucous carcinoma, but CC has a propensity for aggressive local invasion, especially into the bone. Therefore, CC can be quite difficult to remove surgically. A 68-year-old man presented with a case of CC mimicking verrucous leukoplakia in the mandibular gingiva. Repeated biopsies showed no malignancy. Local resection was performed, and histological examination revealed the presence of well-differentiated SCC. Additional hemi-mandibulectomy was performed and the final histological diagnosis was CC. Local recurrence was detected at the 14-month follow-up examination. Chemotherapy with docetaxel was not effective, and he died of aspiration pneumonia. CC of the oral cavity is a rare entity and the diagnosis is hard to establish. Misdiagnosis could result in inadequate removal and local recurrence. Complete resection with a safety margin is essential because of the tendency for local invasion. (C) 2011 Elsevier Ireland Ltd. All rights reserved.