Hemodynamic differences between the awake and anesthetized conditions in normal calves.
Hemodynamic differences between the awake and anesthetized conditions in normal calves.
复制标题
正常小牛清醒和麻醉状态下的血流动力学差异。
DOI：
10.1007/s10047-012-0636-6
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Fukamachi,Kiyotaka
中科院分区：
文献类型：
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作者：
Takaseya,Tohru;Fujiki,Masako;Shiose,Akira;Kim,Hyun-Il;Kobayashi,Mariko;Massiello,AlexL;Dessoffy,Raymond;Al-Ruzzeh,Sharif;Fukamachi,Kiyotaka
在进行大量医学研究的情况下，关于麻醉与术后清醒状态下正常犊牛的基线循环参数的文献资料不足。11头平均体重78.1±14.3 kg的犊牛被植入了流量探头和充液压力线，测量心排血量（CO）、主动脉（AoP）、中心静脉（CVP）、肺动脉（PAP）和左房压（LAP）。同时计算全身血管阻力（SVR）和肺血管阻力（PVR）。我们在异氟醚麻醉下的开胸手术中获得了上述血流动力学数据（n= 11）和心外膜超声心动图（n= 7）。手术完全恢复后，在术后6-9天清醒状态下使用经胸超声心动图（n= 7）和记录血流动力学监测线和探头（n= 11）对动物进行评估。麻醉状态下CO、AoP、PAP水平明显低于清醒状态。其他血流动力学参数（CVP、LAP、SVR和PVR）无显著差异。总之，本研究的数据量化了麻醉小牛CO、AoP和PAP的变化，这些变化可能影响对实验性治疗（如新的心脏辅助装置、假瓣膜和手术干预）的血流动力学反应。我们的研究还提供了将小牛急性体内研究中获得的血流动力学数据转化为清醒受试者的基线数据。
There is insufficient information in the literature about baseline circulatory parameters in normal calves in the anesthetized versus postoperative awake conditions under which a large volume of medical research is conducted. Eleven calves (mean body weight, 78.1 ± 14.3 kg) were implanted with a flow probe and fluid-filled pressure lines to measure cardiac output (CO), aortic (AoP), central venous (CVP), pulmonary arterial (PAP), and left atrial pressures (LAP). Systemic (SVR) and pulmonary vascular resistance (PVR) were also calculated. We obtained the above hemodynamic data (n= 11) and epicardial echocardiography (n= 7) during open-chest surgery under isoflurane anesthesia. After full recovery from surgery, animals were evaluated in the awake condition on postoperative days 6–9 using transthoracic echocardiography (n= 7) and the hemodynamic monitoring lines and probes noted (n= 11). CO, AoP, and PAP levels in the anesthetized condition were significantly lower than in the awake condition. Other hemodynamic parameters (CVP, LAP, SVR, and PVR) were not significantly different. In conclusion, data from this study quantify changes in CO, AoP, and PAP in anesthetized calves that may affect the hemodynamic response to experimental therapeutics such as new cardiac assist devices, prosthetic valves, and surgical interventions. Our study also provides baseline data for the translation of the hemodynamic data obtained in acute in vivo calf studies to that of an awake subject.