Multi-Channel Acquisition for Isotropic Resolution in Magnetic Particle Imaging.
Multi-Channel Acquisition for Isotropic Resolution in Magnetic Particle Imaging.
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DOI：
10.1109/tmi.2017.2787500
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发表时间：
2018-09
影响因子：
10.6
通讯作者：
Conolly S
中科院分区：
文献类型：
--
作者：
Lu K;Goodwill P;Zheng B;Conolly S
磁粒子成像（MPI）是一种对生物相容性超顺磁性氧化铁示踪剂进行成像的分子成像模式，非常适合于临床血管造影、体内细胞跟踪、癌症检测和炎症成像。MPI对示踪剂浓度敏感且定量，具有不被组织背景衰减或破坏的正对比度。与其他临床成像技术（如计算机断层扫描、磁共振成像和核医学）一样，MPI可以被建模为线性和平移不变系统，并具有捕获系统模糊的定义明确的点扩散函数（PSF）。正如我们在这里所展示的，关键的区别在于MPI PSF高度依赖于扫描参数，并且仅使用单个成像轨迹是各向异性的。这种各向异性分辨率对清晰准确的临床诊断提出了重大挑战。在本文中，我们推广了张量成像理论的多维x空间MPI探索这种各向异性的物理来源，提出了一种多通道扫描算法，使各向同性的分辨率，并通过实验证明各向同性MPI分辨率的建设和使用两个正交的激励和检测线圈对。
Magnetic Particle Imaging (MPI), a molecular imaging modality that images biocompatible superparamagnetic iron oxide tracers, is well-suited for clinical angiography, in vivo cell tracking, cancer detection, and inflammation imaging. MPI is sensitive and quantitative to tracer concentration, with a positive contrast that is not attenuated or corrupted by tissue background. Like other clinical imaging techniques such as computed tomography, magnetic resonance imaging, and nuclear medicine, MPI can be modeled as a linear and shift-invariant system with a well-defined point spread function (PSF) capturing the system blur. The key difference, as we show here, is that the MPI PSF is highly dependent on scanning parameters and is anisotropic using only a single imaging trajectory. This anisotropic resolution poses a major challenge for clear and accurate clinical diagnosis. In this paper, we generalize a tensor imaging theory for multidimensional x-space MPI to explore the physical source of this anisotropy, present a multi-channel scanning algorithm to enable isotropic resolution, and experimentally demonstrate isotropic MPI resolution through the construction and use of two orthogonal excitation and detector coil pairs.