POLYENE TOXICITY IN RENAL MEDULLA - INJURY MEDIATED BY TRANSPORT ACTIVITY
POLYENE TOXICITY IN RENAL MEDULLA - INJURY MEDIATED BY TRANSPORT ACTIVITY
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DOI：
10.1126/science.6322305
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
EPSTEIN, FH
中科院分区：
文献类型：
--
作者：
BREZIS, M;ROSEN, S;EPSTEIN, FH
多烯抗生素如两性霉素和制霉菌素可增加膜的通透性和活跃电解质运输中消耗的氧气量。在离体灌注大鼠肾脏中，多烯对髓质厚升肢（肾单位 O2 供应有限的部分）造成广泛损伤。如果哇巴因抑制重吸收转运，则可以防止这种损害。这些情况下的细胞死亡似乎是由运输活动所需的氧气增加介导的。
Polyene antibiotics such as amphotericin and nystatin increase membrane permeability and the amount of O2 consumed in active electrolyte transport. In isolated perfused rat kidneys, the polyenes produced extensive injury to the medullary thick ascending limb, a segment of the nephron with limited O2 supply. This damage was prevented if reabsorptive transport was inhibited by ouabain. Cell death under these circumstances appeared to be mediated by increased O2 demand for transport activity.