A pharmacokinetic study of ethyl glucuronide in blood and urine: Applications to forensic toxicology
A pharmacokinetic study of ethyl glucuronide in blood and urine: Applications to forensic toxicology
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DOI：
10.1016/j.forsciint.2007.01.005
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发表时间：
2007-10-25
影响因子：
2.2
通讯作者：
Morland, Jorg
中科院分区：
文献类型：
--
作者：
Hoiseth, Gudrun;Bernard, Jean Paul;Morland, Jorg
这项药代动力学研究研究了乙醇及其代谢物乙基葡萄糖醛酸（EtG）在血液和尿液中在吸收和消除的整个过程中的动力学。之前关于血液中 EtG 动力学的研究很少，我们想要评估这些知识是否可以在法医案件（例如醉酒驾驶）中提供有关乙醇摄入时间的有价值的信息。 10 名男性志愿者在禁食状态下以 0.5 g/kg 体重的固定剂量摄入乙醇。开始饮酒后 14 小时收集血样，45-50 小时收集尿样。EtG 在中位 4 小时（范围 3.5-5）后达到血液中的最大浓度（C-max），乙醇在 C-max 后中位 3 小时（范围 2-4.5）。仅在饮酒后第一个中位 3.5 小时（范围 2.5-3.5）内，血液中乙醇与 EtG 的比率（乙醇以 g/L 为单位，EtG 以 mg/L 为单位）> 1。 EtG 消除的中位半衰期为 2.2 小时（范围 1.7-3.1 小时），肾清除率为 8.32 L/h（中位范围 5.25-20.86）。尿液中 EtG 的浓度始终远高于血液中的浓度。尿液中排出的 EtG 总量中位数为 30 mg（范围 21.5-39.7），占所给乙醇的 0.017%（中位数，范围 0.013-0.022）（以摩尔计）。本研究的信息可能是确定乙醇摄入时间的有价值的补充。为此，两个随后增加的 EtG 值和血液中较高的乙醇与 EtG 比率将支持近期饮酒的信息。 (c) 2007 Elsevier Ireland Ltd. 保留所有权利。
This pharmacokinetic study investigated the kinetics of ethanol and its metabolite ethyl glucuronide (EtG) in blood and urine during the whole time course of absorption and elimination. There are few previous studies on the kinetics of EtG in blood, and we wanted to evaluate whether such knowledge could yield valuable information regarding the time of ethanol ingestion in forensic cases, such as, for instance, drunk driving.Ten male volunteers consumed ethanol at a fixed dose of 0.5 g/kg body weight in a fasted state. Blood samples were collected for 14 h and urine samples were collected for 45-50 h after the start of drinking.EtG reached its maximum concentration (C-max) in blood after a median of 4 h (range 3.5-5), a median of 3 h (range 2-4.5) after C-max for ethanol. The ethanol-to-EtG ratios in blood (ethanol in g/L, EtG in mg/L) were > 1 only for the first median 3.5 h (range 2.5-3.5) after drinking. EtG elimination occurred with a median half-life of 2.2 h (range 1.7-3.1 h), and the renal clearance was 8.32 L/h (median, range 5.25-20.86). The concentrations of EtG were always much higher in urine than in blood. The total amount of EtG excreted in the urine was median 30 mg (range 21.5-39.7), representing 0.017% (median, range 0.013-0.022) of the ethanol given, on a molar basis.The information from the present study may be a valuable supplement to determine the time of ethanol ingestion. For this purpose, two subsequent increasing EtG values and a high ethanol-to-EtG ratio in blood would support information of recent drinking. (c) 2007 Elsevier Ireland Ltd. All rights reserved.