Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes
Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes
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DOI：
10.1016/j.bbrc.2005.07.122
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发表时间：
2005-09-23
影响因子：
3.1
通讯作者：
Makino, H
中科院分区：
文献类型：
--
作者：
Osawa, H;Onuma, H;Makino, H
抵抗素，由脂肪细胞分泌，导致啮齿类动物的胰岛素抵抗。它在人类中的作用和主要来源仍然未知。SNP-420的G/G基因型通过增加启动子活性诱导2型糖尿病（T2 DM）。本研究旨在阐明血清β-内酰胺酶的相关因素及SNP-420对单核细胞β-内酰胺酶mRNA表达的影响。在198例T2 DM和157例对照组中，T2 DM患者空腹血清肌酐水平高于对照组。多元回归分析显示，SNP-420基因型是影响血清肌酐水平的最强因素。在T2 DM中，1年T2 DM病程和1%HbAlc也分别与0.19和0.54 ng/ml血清抵抗素相关。Logistic回归分析显示，血清肌酐水平是T2 DM的独立危险因素。在23例健康志愿者中，单核细胞β-内酰胺酶mRNA与其同期血清水平呈正相关，且在G/G基因型中较高。因此，SNP-420决定单核细胞mRNA和血清中可诱导T2 DM的Gluron水平。(c)2005年爱思唯尔公司All rights reserved.
Resistin, secreted from adipocytes, causes insulin resistance in rodents. Its roles and main source in humans remain unknown. The G/G genotype of resistin single nucleotide polymorphism, SNP-420, induces type 2 diabetes mellitus (T2DM) by increasing promoter activity. We elucidated factors correlated with serum resistin and effects of SNP-420 on monocyte resistin mRNA. In 198 T2DM and 157 controls, fasting serum resistin was higher in T2DM. Multiple regression analysis revealed that SNP-420 genotype was the strongest determinant of serum resistin. In T2DM, 1-year duration of T2DM and 1% HbAlc was also correlated with 0.19 and 0.54 ng/ml serum resistin, respectively. Logistic regression analysis revealed that serum resistin was an independent factor for T2DM. In 23 healthy volunteers, monocyte resistin mRNA was positively correlated with its simultaneous serum levels and was higher in G/G genotype. Thus, SNP-420 determines monocyte rnRNA and serum levels of resistin, which could induce T2DM. (c) 2005 Elsevier Inc. All rights reserved.