Immune modulating effects of β-glucan
Immune modulating effects of β-glucan
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DOI：
10.1097/mco.0b013e32833f1afb
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发表时间：
2010-11-01
影响因子：
3.1
通讯作者：
Carmichael, Martin D.
中科院分区：
文献类型：
--
作者：
Murphy, E. Angela;Davis, J. Mark;Carmichael, Martin D.
综述目的为了检查最近关于β-葡聚糖的免疫调节作用及其对感染和癌症的益处的科学文献，最近的研究发现β-葡聚糖具有预防感染和癌症的能力，最近还研究了其与癌症治疗相结合的治疗潜力。它们的免疫调节作用归因于与模式识别受体结合的能力，所述模式识别受体包括补体受体3、清道夫受体、乳糖神经酰胺和dectin-1，其导致取决于所涉及的细胞类型和物种的免疫应答的不同方面的激活，尽管关于这些受体中的每一个的相对重要性存在一些争议。大多数可用证据来自临床前数据，而人类研究刚刚开始出现在文献中，因此尚不能对其临床重要性做出确切结论。也许迄今为止在人体试验中最有希望的证据来自最近的研究，即β-葡聚糖与癌症治疗联合使用对生活质量和生存率的益处。我们确定了未来研究的需要，比较不同来源的β-葡聚糖的纯化形式，以进一步了解作用机制，并帮助临床研究的发展。更好地理解β-葡聚糖识别和随后的免疫激活机制对于在未来的临床试验中设计有效的治疗方法是必要的。
Purpose of reviewTo examine the recent scientific literature on the immune modulating effects of beta-glucans and subsequent benefits on infection and cancer.Recent findingsbeta-Glucans have been investigated for their ability to protect against infection and cancer and more recently for their therapeutic potential when combined with cancer therapy. Their immune modulating effects are attributed to the ability to bind to pattern recognition receptors including complement receptor 3, scavenger receptors, lactosylceramide, and dectin-1 that results in activation of different aspects of the immune response depending on the cell types and species involved although there is some controversy about the relative importance of each of these receptors. Most of the available evidence comes from preclinical data and human studies are just now beginning to appear in the literature, therefore firm conclusions on its clinical importance cannot yet be made. Perhaps the most promising evidence to date in human trials has come from recent studies on a benefit of beta-glucan on quality of life and survival when given in combination with cancer treatment. We identify the need for future studies that compare purified forms of beta-glucans from different sources to further the understanding of the mechanisms of action and aid in the development of clinical studies.Summarybeta-Glucans appear to be effective at enhancing immune function and reducing susceptibility to infection and cancer. A better understanding of the mechanisms of beta-glucan recognition and subsequent immune activation is necessary for the design of effective treatment approaches in future clinical trials.