Urinary creatinine excretion and protein/creatinine ratios vary by body size and gender in children
Urinary creatinine excretion and protein/creatinine ratios vary by body size and gender in children
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DOI：
10.1007/s00467-005-0001-6
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发表时间：
2006-05-01
影响因子：
3
通讯作者：
Mayumi, M
中科院分区：
文献类型：
--
作者：
Mori, Y;Hiraoka, M;Mayumi, M
尿蛋白/肌酐比值（Up/Cr）是一种简单的蛋白尿评价指标。然而，身体大小和性别对尿肌酐排泄和Up/Cr的确切影响仍然未知。我们的目的是澄清其影响。收集了124例泌尿系统疾病患儿的晨尿。计算尿肌酐每小时排泄量、Ucr（单位：mg/h）、尿蛋白每小时排泄量/体表面积、Up（mg/m2/h）和Up/cr（mg/mg）。采用多元线性回归模型分析性别、年龄、身高、体重和体表面积对Ucr和Up/cr的影响。体表面积和性别对Ucr有影响（r（2）=0.842，P < 0.0001）。经体表面积校正的尿肌酐随体表面积的增加而增加，但变化幅度不大。Up/cr与Up密切相关，并受身高和性别的影响。回归方程表明，Up/cr值对应于Up的正常上限，即，4 mg/m2/h时，身高170 cm的男孩和女孩中的剂量约为身高80 cm儿童的三分之一（男孩为0.121 vs 0.043，女孩为0.132 vs 0.047）。本研究表明，估计Up/cr需要考虑儿童的身高和性别。
Urinary protein/creatinine ratio (Up/cr) is a simple measurement for evaluation of proteinuria. However, exact effects of body size and gender on urinary excretion of creatinine and Up/cr remain unknown. We aimed to clarify their effects. Early morning urine samples were collected from 124 children with urinary tract disorders. Urinary hourly excretion of creatinine, Ucr (in milligrams per hour), urinary hourly excretion of protein per body surface area, Up (milligrams per square meter per hour), and Up/cr (milligrams per milligram) were calculated. Effects of gender, age, body height, body weight and body surface area on Ucr and Up/cr were analyzed, respectively, in a multiple linear regression model. Body surface area and gender affected Ucr (r(2)=0.842, P < 0.0001). Ucr adjusted by body surface area increased as body surface area grew with moderate variation. Up/cr showed a close correlation with Up and was affected by body height and gender as well. The regression equation showed that Up/cr values corresponding to the normal upper limit of Up, i.e., 4 mg/m(2)/h, in boys and girls 170 cm tall were approximately one third of those in children 80 cm tall (0.121 vs 0.043 for boys, 0.132 vs 0.047 for girls). The present study indicates that estimation of Up/cr needs to include consideration of children's body height and gender.