Carbon Monoxide and Its Controlled Release: Therapeutic Application, Detection, and Development of Carbon Monoxide Releasing Molecules (CORMs)
Carbon Monoxide and Its Controlled Release: Therapeutic Application, Detection, and Development of Carbon Monoxide Releasing Molecules (CORMs)
复制标题
一氧化碳及其受控释放：一氧化碳释放分子 (CORM) 的治疗应用、检测和开发。
DOI：
10.1021/acs.jmedchem.6b01153
复制
发表时间：
2018-04-12
影响因子：
7.3
通讯作者：
Ye, Da-Wei
中科院分区：
文献类型：
--
作者：
Ling, Ken;Men, Fang;Ye, Da-Wei
一氧化碳（CO）因其作为具有细胞保护和稳态特性的气体递质的作用而受到越来越多的关注。一氧化碳释放分子 (CORM) 是空间和时间上受控的 CO 释放剂，由于其化学和结构，其比气态 CO 表现出更优越、更有效的药物特性。动物模型的实验和临床前研究已经显示了吸入CO和CORM的治疗潜力，并且在临床前试验中也通过血红素加氧酶-1（HO-1）的基因调节观察到CO和CORM的生物效应。在这篇综述中，我们描述了 CO 和 CORMS 的制药用途、检测 CO 释放的方法以及 CORM 设计和合成的进展。还描述了许多使用大分子和纳米材料配制的有价值的临床 CORM。
Carbon monoxide (CO) is attracting increasing attention because of its role as a gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing molecules (CORMs) are spatially and temporally controlled CO releasers that exhibit superior and more effective pharmaceutical traits than gaseous CO because of their chemistry and structure. Experimental and preclinical research in animal models has shown the therapeutic potential of inhaled CO and CORMs, and the biological effects of CO and CORMs have also been observed in preclinical trials via the genetic modulation of heme oxygenase-1 (HO-1). In this review, we describe the pharmaceutical use of CO and CORMS, methods of detecting CO release, and developments in CORM design and synthesis. Many valuable clinical CORMs formulated using macromolecules and nanomaterials are also described.