A major susceptibility locus for leprosy in India maps to chromosome 10p13
A major susceptibility locus for leprosy in India maps to chromosome 10p13
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DOI：
10.1038/86958
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发表时间：
2001-04-01
期刊：
影响因子：
30.8
通讯作者：
Hill, AVS
中科院分区：
文献类型：
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作者：
Siddiqui, MR;Meisner, S;Hill, AVS
麻风病是一种由麻风分枝杆菌引起的慢性传染病，在印度流行，约占世界估计80万病例的一半（1）。家族聚集、双生子研究、复杂分离分析和人类白细胞抗原（HLA）相关研究表明，宿主遗传学在麻风易感性可变中的作用。我们在这里报告的224个家庭的基因组的遗传连锁扫描从印度南部，包含245个独立的受影响的同胞与麻风病，主要是少杆菌型。在利用396个微卫星标记进行的两阶段基因组筛选中，我们发现了显著的连锁（最大lod得分（MLS）=4.09，P
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur(1). A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected sibpairs with leprosy, mainly of the paucibacillary type. In a two-stage genome screen using 396 microsatellite markers, we found significant linkage (maximum lod score (MLS)=4.09, P