Analysis of surface whitening of extracted hydrophobic acrylic intraocular lenses
Analysis of surface whitening of extracted hydrophobic acrylic intraocular lenses
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DOI：
10.1016/j.jcrs.2009.07.004
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发表时间：
2009-11-01
影响因子：
2.8
通讯作者：
Senoo, Tadashi
中科院分区：
文献类型：
--
作者：
Matsushima, Hiroyuki;Mukai, Koichiro;Senoo, Tadashi
目得：目的：确定Acry-Sof人工晶状体（IOL）表面光散射（即变白）的原因。单位：日本都京医科大学眼科。方法：储存从3例患者中取出的脱位IOL，并在光学显微镜下检查IOL表面。通过用分光光度计测量光透射来评估美白对视觉功能的影响。为了确定混浊的原因，使用电子探针X射线显微分析仪检查IOL的磷酸钙沉积。还通过傅里叶变换红外分光光度法检查了人工晶状体表面，包括是否存在有机沉积物和水解证据。结果：所有人工晶状体的视区表面均因变白而混浊。360 - 800 nm可见光范围内的光透射率比未使用的IOL低4%。X射线微区分析显示无磷酸钙沉积。IOL光学部材料的傅立叶变换红外分光光度法显示无水解迹象。混浊消失后的IOL干燥，然后重新出现随着时间的推移，当IOL再次浸入生理盐水。结论：研究结果强烈表明，美白的疏水性丙烯酸IOL是由于微量水分子渗透的光学。在聚合物透镜材料的三维网络内，分子太小而不能形成可观察到的空隙，但可以形成足够大小的水聚集体以散射可见光，从而导致浑浊（即，变白）。白内障屈光手术杂志2009; 35：1927-1934（C）2009 ASCRS和ESCRS
PURPOSE: To identify the cause of light scattering on the surface (ie, whitening) of extracted Acry-Sof intraocular lenses (IOLs).SETTING: Department of Ophthalmology, Dokkyo Medical University, Tochigi, Japan.METHODS: Dislocated IOLs extracted from 3 patients were stored and the IOL surfaces examined under light microscopy. The effect of whitening on visual function was evaluated by measuring light transmission with a spectro photo meter. To determine the cause of opacification, the IOLs were examined for calcium phosphate deposits using an electron probe X-ray microanalyzer. The IOL surface, including the presence of organic deposits and evidence of hydrolysis, was also examined by Fourier-transform infrared spectrophotometry. The IOLs were then dried, immersed again in physiological saline, and serially examined for changes in opacification.RESULTS: The optic surfaces of all IOLs had opacification due to whitening. Light transmission in the visible range of 360 to 800 nm was 4% less than that of unused IOLs. The X-ray microanalysis showed no calcium phosphate deposits. Fourier-transform infrared spectrophotometry of the IOL optic material showed no evidence of hydrolysis. Opacification disappeared after the IOLs were dried and then reappeared over time when the IOL was immersed again in physiologic saline.CONCLUSIONS: The findings strongly suggest that whitening of the hydrophobic acrylic IOL was due to trace water molecules that infiltrate the optic. Within the 3-dimensional network of the polymeric lens material, the molecules are too small to form observable voids but can form water aggregates of sufficient size to scatter visible light, causing opacification (ie, whitening). J Cataract Refract Surg 2009; 35:1927-1934 (C) 2009 ASCRS and ESCRS