Neural correlates of auditory-visual stimulus onset asynchrony detection
Neural correlates of auditory-visual stimulus onset asynchrony detection
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DOI：
10.1523/jneurosci.21-01-00300.2001
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发表时间：
2001-01-01
影响因子：
5.3
通讯作者：
Hallett, M
中科院分区：
文献类型：
--
作者：
Bushara, KO;Grafman, J;Hallett, M
感觉跨性时同步是一种普遍存在的感觉属性，事实证明，对绑定多感官输入至关重要，有时会错误地导致戏剧性的感知幻觉。然而，关于大脑如何检测多模式感觉输入之间的时间同步知之甚少。我们使用正电子发射断层扫描来证明，检测听觉 - 视觉刺激发作异步异步会激活一个大规模的神经网络，该网络具有孤立的，后顶叶，前额叶，前额叶和小脑区域，其最高和特定于任务的活性位于正确的胰岛素中。区域间协方差分析进一步显示，岛，丘脑后和上丘之间的任务相关功能相互作用显着。基于这些结果以及动物中可用的电生理和解剖连通性数据，我们建议岛通过其已知的短期延迟连接与构造系统的短期连接，在皮质处理的早期阶段介导时间定义的听觉 - 视觉相互作用，允许这种现象这样的现象。作为腹膜和麦格克的幻觉。
Intersensory temporal synchrony is an ubiquitous sensory attribute that has proven to be critical for binding multisensory inputs, sometimes erroneously leading to dramatic perceptual illusions. However, little is known about how the brain detects temporal synchrony between multimodal sensory inputs. We used positron emission tomography to demonstrate that detecting auditory-visual stimulus onset asynchrony activates a large-scale neural network of insular, posterior parietal, prefrontal, and cerebellar areas with the highest and task-specific activity localized to the right insula. Interregional covariance analysis further showed significant task-related functional inter-actions between the insula, the posterior thalamus, and superior colliculus. Based on these results and the available electrophysiological and anatomical connectivity data in animals, we propose that the insula, via its known short-latency connections with the tectal system, mediates temporally defined auditory-visual interaction at an early stage of cortical processing permitting phenomena such as the ventriloquist and the McGurk illusions.