Burnout Is Associated with Reduced Parasympathetic Activity and Reduced HPA Axis Responsiveness, Predominantly in Males.
Burnout Is Associated with Reduced Parasympathetic Activity and Reduced HPA Axis Responsiveness, Predominantly in Males.
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DOI：
10.1155/2015/431725
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发表时间：
2015
影响因子：
--
通讯作者：
Emmelkamp PM
中科院分区：
文献类型：
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作者：
de Vente W;van Amsterdam JG;Olff M;Kamphuis JH;Emmelkamp PM
越来越多的证据表明，倦怠是心血管疾病（CVD）的危险因素。压力相关的交感神经和副交感神经系统以及下丘脑-垂体-肾上腺（HPA）轴的失调可以解释CVD风险的增加。为了验证这一假设，55例（34名男性和21名女性）与职业倦怠的病假和40名健康参与者（16名男性和24名女性）暴露于心理社会应激源，包括心算和公开演讲。生理变量（即，测量血压、心率、心输出量、血管阻力、皮质醇和α-淀粉酶）。比较两组之间的基础水平、反应性和恢复。在男性患者中，基线收缩压高于健康男性，而基础α-淀粉酶和皮质醇反应性低于健康男性。在女性患者中，发现与健康女性相比，基础皮质醇有降低的趋势。此外，在男性和女性患者中均观察到基础心率变异性降低和基础心输出量升高的趋势。倦怠的特征是交感神经和副交感神经系统以及HPA轴的失调，男性比女性更明显。这项研究进一步支持倦怠是心血管疾病的危险因素，通过交感神经和副交感神经系统和HPA轴的失调。
There is mounting evidence that burnout is a risk factor for cardiovascular disease (CVD). Stress-related dysregulation of the sympathetic and parasympathetic system and the hypothalamic pituitary adrenal (HPA) axis may explain the enhanced risk for CVD. To test this hypothesis, 55 patients (34 males and 21 females) with burnout on sickness absence and 40 healthy participants (16 males and 24 females) were exposed to a psychosocial stressor consisting of mental arithmetic and public speech. Physiological variables (i.e., blood pressure, heart rate, cardiac output, vascular resistance, cortisol, and alpha-amylase) were measured. Basal levels, reactivity, and recovery were compared between groups. In male patients, baseline systolic blood pressure was higher, whereas basal alpha-amylase and cortisol reactivity were lower than in healthy males. In female patients, a tendency for lower basal cortisol was found as compared to healthy females. Furthermore, reduced basal heart rate variability and a trend for elevated basal cardiac output were observed in both male and female patients. Burnout is characterised by dysregulation of the sympathetic and parasympathetic system and the HPA axis, which was more pronounced in males than in females. This study further supports burnout as being a risk factor for CVD through dysregulation of the sympathetic and parasympathetic system and the HPA axis.