Synthesis of 3-methoxyolivacine and olivacine by Friedel-Crafts reaction of indole-2,3-dicarboxylic anhydride with 2,4,6-trimethoxypyridine
Synthesis of 3-methoxyolivacine and olivacine by Friedel-Crafts reaction of indole-2,3-dicarboxylic anhydride with 2,4,6-trimethoxypyridine
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DOI：
10.1055/s-2004-831317
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发表时间：
2004-10-01
期刊：
影响因子：
2
通讯作者：
Aoki, Y
中科院分区：
文献类型：
--
作者：
Miki, Y;Tsuzaki, Y;Aoki, Y
1-苄基吲哚-2，3-二羧酸酐（1）与2，4，6-三甲氧基吡啶在氯化钛（IV）存在下反应，高产率地得到3-（2，4，6-三甲氧基烟酰基）吲哚-2-甲酸（2），该产物可转化为橄榄碱。
1-Benzylindole-2,3-dicarboxylic anhydride (1) was reacted with 2,4,6-trimethoxypyridine in the presence of titanium(IV) chloride to give 3-(2,4,6-trimethoxynicotinoyl)indole-2-carboxylic acid (2) as the sole product in high yield, which could be converted to olivacine.