Relation between myocyte disarray and outcome in hypertrophic cardiomyopathy
Relation between myocyte disarray and outcome in hypertrophic cardiomyopathy
复制标题
DOI：
10.1016/s0002-9149(01)01640-x
复制
发表时间：
2001-08-01
影响因子：
2.8
通讯作者：
McKenna, WJ
中科院分区：
文献类型：
--
作者：
Varnava, AM;Elliott, PM;McKenna, WJ
肥厚型心肌病（HC）与心源性猝死或心力衰竭死亡的风险增加有关。对于这种疾病中过早死亡风险的病理学基础知之甚少。因此，我们着手将75例HC患者的病理结果与死亡模式和风险特征相关联。具有HC的心脏是在死亡或移植后获得的。临床细节与每个心脏的19个切片的肉眼发现和纤维化百分比、紊乱和小血管疾病相关。猝死39例，终末期心力衰竭28例，其他原因死亡8例。心肌细胞紊乱与缺血性证据呈正相关（r = 0.5，p
Hypertrophic cardiomyopathy (HC) is associated with an increased risk of sudden cardiac death or death from heart failure. Little is known of the pathologic substrate for risk of premature death in this disease. We therefore set out to correlate the pathologic findings with the mode of death and risk profile in 75 patients with HC. Hearts with HC were obtained after death or transplantation. The clinical details were correlated with the macroscopic findings and the percent fibrosis, disarray, and small-vessel disease across 19 sections of each heart. Thirty-nine patients died suddenly, 28 had end-stage heart failure, and 8 died of other causes. Myocyte disarray correlated positively with evidence of ischemic (r = 0.5, p