Elevated glial brain-derived neurotrophic factor in Parkinson's diseased nigra
Elevated glial brain-derived neurotrophic factor in Parkinson's diseased nigra
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DOI：
10.1016/s1353-8020(02)00008-1
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发表时间：
2002-06-01
影响因子：
4.1
通讯作者：
Wilkin, GP
中科院分区：
文献类型：
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作者：
Knott, C;Stern, G;Wilkin, GP
我们显示了脑源性神经营养因子（BDNF），神经营养素-3（NT-3）和酪氨酸激酶受体TRKB和TRKC在特发性帕金森病（IPD）和对照组死后的免疫反应性（IR）的细胞分布。在两组中，黑质神经元，星形胶质细胞，分枝和变形小胶质细胞表达所有抗原。尾壳核神经元表达除BDNF外的所有抗原，组间分布相似。在IPD黑质中，BDNF-IR和较少出现的NT-3-IR分支胶质细胞的数量增加，围绕碎片神经元，伴随着周围神经元中的BDNF-IR。变形样小胶质细胞仅在IPD黑质瘢痕中丰富。在IPD中，胶质细胞可能上调神经营养因子，以响应从黑质神经元衰竭释放的信号。(C)2002年由Elsevier Science Ltd.出版
We show the cellular distribution of immunoreactivity (IR) for brain-derived-neurotrophic-factor (BDNF), neurotrophin-3 (NT-3) and tyrosine kinase receptors TRKB and TRKC in idiopathic Parkinson's disease (IPD) and controls at post-mortem. In both groups, nigral neurons, astrocytes, ramified and amoeboid microglia expressed all antigens. Caudate-putamen neurons expressed all antigens except BDNF with similar distribution between groups. In IPD nigra, increased numbers of BDNF-IR and, less frequently, NT-3-IR ramified glia surrounded fragmented neurons, accompanied by BDNF-IR in surrounding neuropil. Amoeboid microglia were abundant only in IPD nigral scars. In IPD, glia might up-regulate neurotrophins in response to signals released from failing nigral neurons. (C) 2002 Published by Elsevier Science Ltd.