Self-administration of drugs in animals and humans as a model and an investigative tool
Self-administration of drugs in animals and humans as a model and an investigative tool
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DOI：
10.1111/j.1360-0443.2007.02011.x
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发表时间：
2007-12-01
期刊：
影响因子：
6
通讯作者：
Goldberg, Steven R.
中科院分区：
文献类型：
--
作者：
Panlilio, Leigh V.;Goldberg, Steven R.
目的简要介绍动物和人体自我给药的研究方法、假设、模型、成就、不足和未来发展方向。背景使用药物自我管理来研究成瘾是基于这样的假设，即药物加强了导致其交付的行为。已经开发了广泛的药物自我给药技术来模拟成瘾的特定方面。这些技术非常适合与各种神经科学技术相结合。结论将药物使用视为药物强化的行为，有助于对成瘾的认识和治疗。作为临床前研究计划的一部分，该计划还涉及使用各种更简单的行为技术进行筛查，药物自我给药程序可以为测试成瘾的潜在治疗方法提供重要的最后一步。目前有一个协调一致的努力，以开发自我管理程序，模型的极端性质的行为所产生的成瘾。随着神经科学技术的不断进步，自我管理应继续提供一种手段，在一个复杂的和有效的人类药物成瘾模型中应用这些技术。
Aims To review briefly the methods, assumptions, models, accomplishments, drawbacks and future directions of research using drug self-administration in animals and humans. Background The use of drug self-administration to study addiction is based on the assumption that drugs reinforce the behavior that results in their delivery. A wide range of drug self-administration techniques have been developed to model specific aspects of addiction. These techniques are highly amenable to being combined with a wide variety of neuroscience techniques. Conclusions The identification of drug use as behavior that is reinforced by drugs has contributed greatly to the understanding and treatment of addiction. As part of a program of pre-clinical research that also involves screening with a variety of simpler behavioral techniques, drug self-administration procedures can provide an important last step in testing potential treatments for addiction. There is currently a concerted effort to develop self-administration procedures that model the extreme nature of the behavior engendered by addiction. As advances continue to be made in neuroscience techniques, self-administration should continue to provide a means of applying these techniques within a sophisticated and valid model of human drug addiction.