Intimate Partner Violence PTSD and Neural Correlates of Inhibition
Intimate Partner Violence PTSD and Neural Correlates of Inhibition
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DOI：
10.1002/jts.22068
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发表时间：
2016-02-01
影响因子：
3.3
通讯作者：
Stein, Murray B.
中科院分区：
文献类型：
--
作者：
Aupperle, Robin L.;Stillman, Ashley N.;Stein, Murray B.
创伤后应激障碍（PTSD）与反应抑制的缺陷有关，神经影像学研究表明这可能是由于前额叶皮层招募的差异。本研究探讨了亲密伴侣暴力（IPV）引起的PTSD与抑制过程中神经反应之间的关系。有10名女性PTSD从IPV和12名女性对照组无创伤史谁完成了功能磁共振成像过程中的停止信号任务。使用线性混合模型研究激活的组间差异（停止-不停止和难-易试验）。PTSD患者在右背外侧前额叶皮层和前额叶皮层对停止-不停止试验的差异激活更大，而在几个默认模式区域的差异激活更小（d = 1.12-1.22）。患有PTSD的受试者在侧额叶和前额叶区域（由对硬试验的较少激活驱动）和几个默认模式区域（即，内侧前额叶皮层，后扣带回;由更大的激活驱动以容易试验; d = 1.23-1.76）。PTSD与在认知需求相对较低的认知任务中难以脱离默认模式区域以及难以随着认知需求的增加调节执行控制和显著性处理区域有关。总之，这些结果表明，PTSD可能与抑制期间神经灵活性降低有关。
Posttraumatic stress disorder (PTSD) has been linked to deficits in response inhibition, and neuroimaging research suggests this may be due to differences in prefrontal cortex recruitment. The current study examined relationships between PTSD from intimate partner violence (IPV) and neural responses during inhibition. There were 10 women with PTSD from IPV and 12 female control subjects without trauma history who completed the stop signal task during functional magnetic resonance imaging. Linear mixed models were used to investigate group differences in activation (stop-nonstop and hard-easy trials). Those with PTSD exhibited greater differential activation to stop-nonstop trials in the right dorsolateral prefrontal cortex and the anterior insula and less differential activation in several default mode regions (d = 1.12-1.22). Subjects with PTSD exhibited less differential activation to hard-easy trials in the lateral frontal and the anterior insula regions (driven by less activation to hard trials) and several default mode regions (i.e., medial prefrontal cortex, posterior cingulate; driven by greater activation to easy trials; d = 1.23-1.76). PTSD was associated with difficulties disengaging default mode regions during cognitive tasks with relatively low cognitive demand, as well as difficulties modulating executive control and salience processing regions with increasing cognitive demand. Together, these results suggest that PTSD may relate to decreased neural flexibility during inhibition.