Partial hepatectomy induces delayed hepatocyte proliferation and normal liver regeneration in ovariectomized mice
Partial hepatectomy induces delayed hepatocyte proliferation and normal liver regeneration in ovariectomized mice
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DOI：
10.2147/ceg.s80212
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发表时间：
2015-01-01
影响因子：
2.4
通讯作者：
Imai, Takeshi
中科院分区：
文献类型：
--
作者：
Umeda, Makoto;Hiramoto, Masaki;Imai, Takeshi
雌激素在性发育、生殖和肝细胞增殖中起重要作用。卵巢是产生雌二醇（E2）的主要器官之一。对雌性小鼠进行卵巢切除术（OVX），并分析肝细胞增殖。卵巢切除小鼠表现出延迟肝细胞增殖后部分肝切除术（PH），也表现出延迟和减少E2诱导。E2给药和PH均诱导雌激素受体a（ERa）基因表达。雌激素受体α的转录本在门脉周围肝细胞中特异性地被检测到，并且在动情周期的动情前期E2浓度和肝细胞增殖率最高。总之，这些发现表明，E2加速雌鼠门静脉周围肝细胞和肝细胞增殖的ER α表达。
Estrogens play central roles in sexual development, reproduction, and hepatocyte proliferation. The ovaries are one of the main organs for estradiol (E2) production. Ovariectomies (OVXs) were performed on the female mice, and hepatocyte proliferation was analyzed. The ovariectomized mice exhibited delayed hepatocyte proliferation after partial hepatectomy (PH) and also exhibited delayed and reduced E2 induction. Both E2 administration and PH induced the gene expression of estrogen receptor a (ERa). The transcripts of ERa were detected specifically in periportal hepatocytes after E2 administration and PH. Moreover, the E2 concentrations and hepatocyte proliferation rates were highest in the proestrus period of the estrous cycle. Taken together, these findings indicate that E2 accelerated ERa expression in periportal hepatocytes and hepatocyte proliferation in the female mice.