An Oxytocin Receptor Gene Variant Predicts Attachment Anxiety in Females and Autism-Spectrum Traits in Males
An Oxytocin Receptor Gene Variant Predicts Attachment Anxiety in Females and Autism-Spectrum Traits in Males
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DOI：
10.1177/1948550611410325
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发表时间：
2012-01-01
影响因子：
5.7
通讯作者：
Johnson, Susan C.
中科院分区：
文献类型：
--
作者：
Chen, Frances S.;Johnson, Susan C.
采用分子遗传学方法研究了催产素受体（OXTR）基因的常见变异与健康成年人自我报告的社会功能之间的关系。在OXTR rs2254298处具有至少一个A等位基因拷贝的女性比具有两个G等位基因拷贝的女性报告了更大的依恋焦虑。在OXTR rs2254298处具有至少一个A等位基因拷贝的男性比具有两个G等位基因拷贝的男性报告更多的自闭症相关性状。这些结果支持了越来越多的证据，即催产素系统中自然发生的差异有助于健康成年人社会功能的个体差异。作者讨论了性可能缓和催产素和人类社会行为之间关系的潜在途径。
A molecular genetic approach was used to investigate the relationship between common variants of the oxytocin receptor (OXTR) gene and self-reported social functioning in healthy adults. Females with at least one copy of the A allele at OXTR rs2254298 reported greater attachment anxiety than females with two copies of the G allele. Males with at least one copy of the A allele at OXTR rs2254298 reported more autism-associated traits than males with two copies of the G allele. These results support the growing evidence that naturally occurring differences in the oxytocin system contribute to individual differences in social functioning in healthy adults. The authors discuss potential avenues by which sex may moderate the relationship between oxytocin and human social behavior.