EEG, heart rate and mood change (“high”) after Cannabis
EEG, heart rate and mood change (“high”) after Cannabis
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大麻后脑电图、心率和情绪变化（“高”）
DOI：
10.1007/bf00421704
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
Max Fink
中科院分区：
文献类型：
--
作者：
Jan Volavka;P. Crown;R. Dornbush;Stanley Feldstein;Stanley Feldstein;Max Fink;Max Fink
14名有经验的大麻使用者吸食大麻，大麻，δ9-THC和安慰剂。记录脑电图、心电图及主观感觉“高”和愉快程度。脑电图经周期分析，大麻和δ9-THC使α活动增加，而三种大麻制剂使β活动减少。吸食大麻、印度大麻和δ9-THC后，α活性的平均频率降低了0.15-0.20 c/sec。EEG效应的峰值出现在吸烟后的前10分钟内; 40分钟后大部分变化消失。所有三种药物均使心率增加，且效应持续整个观察期（50分钟）。这并不适用于体验的愉快程度：只有大麻和印度大麻被认为比安慰剂更令人愉快。“高”的强度随着α活动的量而增加，并且随着平均α频率而降低。愉悦感与脑电图无关，“高”与心率呈线性关系，而愉悦感与心率呈倒U型函数关系。
Fourteen experienced marijuana users smoked marijuana, hashish, δ9-THC, and placebo. EEG, ECG and ratings of subjective feelings of “high” and pleasantness were recorded. EEGs were processed by period analysis.In EEG, marijuana and δ9-THC increased the amount of alpha activity, and the three Cannabis preparations decreased the amount of beta activity. The average frequency of alpha activity was decreased by 0.15–0.20 c/sec after marijuana, hashish and δ9-THC. The peak EEG effect occurred during the first 10 min after smoking; most of the changes disappeared after 40 min. Heart rate was increased by all the three drugs, and the effect persisted for the entire observation period (50 min).Feelings of “high” were elicited by each Cannabis preparation. This was not true of the pleasantness of the experience: only marijuana and hashish were perceived as more pleasant than placebo. Intensity of “high” increased with the amount of alpha activity, and decreased with the average alpha frequency. Pleasantness was unrelated to the EEG.The “high” showed a linear increase with heart rate, whereas pleasantness of the experience was an inverted U-function of heart rate.