oxLDL/β2GPI complex and anti-oxLDL/β2GPI in SLE: Prevalence and correlates
oxLDL/β2GPI complex and anti-oxLDL/β2GPI in SLE: Prevalence and correlates
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DOI：
10.1080/08916930902828247
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发表时间：
2009-01-01
期刊：
影响因子：
3.5
通讯作者：
Doria, A.
中科院分区：
文献类型：
--
作者：
Bassi, N.;Zampieri, S.;Doria, A.
高水平的氧化低密度脂蛋白/ β 2糖蛋白1 （oxLDL/ β 2GPI）复合物和抗复合物IgG以及IgM在SLE中已被报道。我们在SLE患者中分析了该复合物和抗该复合物的Ab，并评估了它们与临床和血清学结果、动脉粥样硬化的传统危险因素和亚临床动脉粥样硬化的关系。系统性红斑狼疮（SLE）患者复合体和抗复合体Ab的患病率和水平明显高于正常健康供者（NHD）。oxLDL/ β 2GPI滴度在肾脏受累和既往血栓栓塞发作的患者中明显较高，并且与动脉粥样硬化危险因素的数量相关，而在神经受累的患者中则明显较低。IgG和IgM抗复合体Ab均与抗磷脂（APL）相关。总之，oxLDL/ β 2GPI复合物以及抗该复合物的Ab在SLE中普遍存在，它们似乎与器官损伤有关。
High levels of oxidized low-density liprotein/beta2 glycoprotein 1 (oxLDL/beta 2GPI) complexes and anti-complex IgG as well as IgM have been reported in SLE. We analysed this complex and Ab against the complex in SLE patients and evaluated their relationship with clinical and serological findings, traditional risk factors for atherosclerosis, and subclinical atherosclerosis. The prevalence and the levels of the complex and of anti-complex Ab were significantly higher in systemic lupus erythematosus (SLE) patients than in normal healthy donors (NHD). The titers of oxLDL/beta 2GPI were significantly higher in patients with renal involvement and previous thromboembolic episodes and were correlated with the number of risk factors for atherosclerosis, whereas they were significantly lower in patients with neurological involvement. Both IgG and IgM anticomplex Ab were associated with antiphospholipid (APL). In conclusion, the oxLDL/beta 2GPI complex as well as Ab against the complex are prevalent in SLE where they seem to be involved in organ damage.