Weight Lifting and Physical Function Among Survivors of Breast Cancer: A Post Hoc Analysis of a Randomized Controlled Trial
Weight Lifting and Physical Function Among Survivors of Breast Cancer: A Post Hoc Analysis of a Randomized Controlled Trial
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DOI：
10.1200/jco.2014.57.7395
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发表时间：
2015-07-01
影响因子：
45.3
通讯作者：
Schmitz, Kathryn H.
中科院分区：
文献类型：
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作者：
Brown, Justin C.;Schmitz, Kathryn H.
目的乳腺癌的幸存者可能会经历身体功能的恶化。这一点很重要，因为身体机能不良可能与过早死亡、损伤性福尔斯、骨折和残疾有关。我们进行了事后分析，以探讨潜在的疗效缓慢渐进举重，以减少乳腺癌.Methods的幸存者之间的身体功能恶化的发病率在2005年10月至2008年8月，我们进行了一项单盲，12个月，随机对照试验，每周两次缓慢渐进举重或标准护理295名非转移性乳腺癌的幸存者。在这项对体力活动和淋巴水肿试验数据的事后分析中，我们检查了12个月后身体功能的事件恶化，结果147例患者中，16.3%（24/147）的患者在治疗12个月后发生了偶发性身体功能恶化，其中147例患者中，147例患者的身体功能下降了10分。对照组和举重组分别为8.1%（12/148）（相对危险度，0.49; 95%CI，0.25 - 0.96; P = 0.04）。没有严重或意外的不良事件发生，与weightlifting.Conclusion缓慢渐进举重与标准护理相比，降低了乳腺癌幸存者的身体功能恶化的发生率。这些数据是假设生成的。未来的研究应该直接比较举重与其他运动方式（如快走）的疗效，以适当地告知旨在保护乳腺癌幸存者身体功能的验证性研究的发展。
Purpose Survivors of breast cancer may experience deterioration of physical function. This is important because poor physical function may be associated with premature mortality, injurious falls, bone fracture, and disability. We conducted a post hoc analysis to explore the potential efficacy of slowly progressive weight lifting to reduce the incidence of physical function deterioration among survivors of breast cancer.Methods Between October 2005 and August 2008, we conducted a single-blind, 12-month, randomized controlled trial of twice-per-week slowly progressive weight lifting or standard care among 295 survivors of nonmetastatic breast cancer. In this post hoc analysis of data from the Physical Activity and Lymphedema Trial, we examined incident deterioration of physical function after 12 months, defined as a 10-point decrease in the physical function subscale of the Medical Outcomes Short-Form 36-item questionnaire.Results The proportion of participants who experienced incident physical function deterioration after 12 months was 16.3% (24/147) in the control group and 8.1% (12/148) in the weight lifting group (relative risk, 0.49; 95% CI, 0.25 to 0.96; P = .04). No serious or unexpected adverse events occurred that were related to weight lifting.Conclusion Slowly progressive weight lifting compared with standard care reduced the incidence of physical function deterioration among survivors of breast cancer. These data are hypothesis generating. Future studies should directly compare the efficacy of weight lifting with other modalities of exercise, such as brisk walking, to appropriately inform the development of a confirmatory study designed to preserve physical function among survivors of breast cancer.