Favorable Response of Chronic Refractory Immune Thrombocytopenic Purpura to Mesenchymal Stem Cells
Favorable Response of Chronic Refractory Immune Thrombocytopenic Purpura to Mesenchymal Stem Cells
复制标题
慢性难治性免疫性血小板减少性紫癜对间充质干细胞的良好反应
DOI：
10.1089/scd.2011.0231
复制
发表时间：
2012-02-10
影响因子：
4
通讯作者：
Song, Yongping
中科院分区：
文献类型：
--
作者：
Fang, Baijun;Mai, Ling;Song, Yongping
七名慢性难治性免疫性血小板减少性紫癜（ITP）患者接受了来自单倍体相同家庭捐赠者的脂肪组织来源的间充质干细胞（AMSC）。AMSC剂量为2.0 x 10（6）/kg。AMSC输注后未观察到副作用。总有效率为57.1%（4/7）。与活动性ITP患者相比，AMSC给药后血清转化生长因子β 1（TGF-β 1）、白细胞介素（IL）-4和IL-10水平显著升高，而干扰素-γ（IFN-γ）和IL-2水平显著降低。在随访期间，与治疗后水平相比，维持持续应答的患者的细胞因子谱保持稳定，但IFN-γ和IL-2水平显著升高，复发患者的TGF-β 1、IL-4和IL-10水平再次显著降低。AMSC治疗似乎是重度、慢性难治性ITP的合理补救治疗，可使Th 1/Th 2细胞因子平衡转移至与正常对照相同的水平。
Seven patients with chronic refractory immune thrombocytopenic purpura (ITP) received adipose tissue-derived mesenchymal stem cells (AMSC) from haplo-identical family donors. The AMSC dose was 2.0 x 10(6)/kg. No side effects were noted after the AMSC infusions. Overall responses were reached in all patients and sustained response rate was 57.1% (4/7). The serum levels of transforming growth factor beta 1 (TGF-beta 1), interleukin (IL)-4, and IL-10 were significantly elevated, whereas those of interferon-gamma (IFN-gamma) and IL-2 were significantly decreased after AMSC administration, compared with those in the patients with active ITP. During follow-up, the cytokine profiles in patients maintaining sustained response remained stable compared with the post-treatment level, but IFN-gamma and IL-2 levels were significantly increased, and those of TGF-beta 1, IL-4, and IL-10 were significantly reduced again in relapsed patients. AMSC therapy seems to represent reasonable salvage treatment in severe, chronic refractory ITP by causing a shift in the Th1/Th2 cytokine balance to the same levels as normal controls.