The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases.
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases.
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蛋白激酶C epsilon 在神经信号转导和神经源性疾病中的作用
DOI：
10.1007/s11684-011-0119-9
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发表时间：
2011-03-01
影响因子：
8.1
通讯作者：
Tian, Qi
中科院分区：
文献类型：
--
作者：
Chen, Yuan;Tian, Qi
蛋白激酶C亚型（PKC β）是新的PKC家族的主要亚型之一。尽管在过去的十年里它已被广泛表征，但PKC在神经元中的作用仍然没有得到很好的理解。随着分子生物学的发展，直接研究PKC β在体内的功能已成为可能，而PKC β在神经生物学功能及相关神经源性疾病中的作用也日益受到重视。最近的研究为PKC对单细胞水平和网络水平皮质加工的影响提供了重要的见解。这些研究提供了有力的证据表明，PKC β可以调节神经信号转导的不同方面，并表明许多分子信号的协调作用有助于发育中的大脑中PKC β信号通路的特化和分化。
Protein kinase C epsilon (PKC ɛ) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ɛ in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ɛ functions in vivo, and PKC ɛ has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ɛ on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ɛ could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ɛ signal pathway in the developing brain.