Selective oxidation of p-phenylenediamine for blood glucose detection enabled by Se-vacancy-rich TiSe2-x@Au nanozyme.
Selective oxidation of p-phenylenediamine for blood glucose detection enabled by Se-vacancy-rich TiSe2-x@Au nanozyme.
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DOI：
10.1016/j.bios.2023.115665
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发表时间：
2023-09
影响因子：
12.6
通讯作者：
Caixia Sun;Xue Zhang;Hao Huang;Ya Liu;Xianwei Mo;Yufei Feng;Jiahong Wang;Wenhua Zhou;Paul K. Chu;Xue-Feng Yu;Wenxin Liu
中科院分区：
文献类型：
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作者：
Caixia Sun;Xue Zhang;Hao Huang;Ya Liu;Xianwei Mo;Yufei Feng;Jiahong Wang;Wenhua Zhou;Paul K. Chu;Xue-Feng Yu;Wenxin Liu
Nanozymes with enzyme-like characteristics have drawn wide interest but the catalytic activity and substrate selectivity of nanozymes still need improvement. Herein, Se-vacancy-rich TiSe2-x@Au nanocomposites are designed and demonstrated as nanozymes. The TiSe2-x@Au nanocomposites show excellent peroxidase-like activity and the chromogenic substrate p-phenylenediamine (PPD) can be selectively oxidized to compounds that exhibit an absorption peak at 413 nm that differs from that of self-oxidation or generally oxidized species, suggesting high catalytic activity and strong substrate selectivity. Theoretical calculations reveal that the PPD adsorption geometry at Se vacancies with an adsorption energy of −3.00 eV shows a unique spatial configuration and charge distribution, thereby inhibiting the free reaction and promoting both the activity and selectivity in PPD oxidation. The TiSe2-x@Au colorimetric system exhibits a wide linear range of 0.015 mM–0.6 mM and a low detection limit of 0.0037 mM in the detection of glucose. The blood glucose detection performance for human serum samples is comparable to that of a commercial glucose meter in the hospital (relative standard deviation < 6%). Our findings demonstrate a new strategy for rapid and accurate detection of blood glucose and our results provide insights into the future design of nanozymes.
