Mitochondrial quality control and neurodegenerative diseases.
Mitochondrial quality control and neurodegenerative diseases.
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DOI：
10.1042/ns20180062
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发表时间：
2018-12-01
影响因子：
--
通讯作者：
Zhang, Jianmin
中科院分区：
文献类型：
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作者：
Gao, Fei;Zhang, Jianmin
线粒体稳态由线粒体质量控制（MQC）系统维持，这对细胞健康至关重要，特别是在维持功能性线粒体方面。健康的线粒体网络对生命至关重要，因为它调节细胞代谢过程，特别是ATP的产生。线粒体动力学和线粒体自噬是MQC系统中两个高度整合的过程，决定着受损线粒体的修复或降解。神经元是高度分化的细胞，需要高能量消耗。因此，受损的MQC过程和功能障碍的线粒体的积累可能是神经元死亡的主要原因，并导致神经变性。在这里，我们专注于线粒体动力学和线粒体自噬的不可分割的关系，以及它们的功能障碍如何导致神经退行性疾病。
Mitochondria homeostasis is sustained by the mitochondrial quality control (MQC) system, which is crucial for cellular health, especially in the maintenance of functional mitochondria. A healthy mitochondria network is essential for life as it regulates cellular metabolism processes, particularly ATP production. Mitochondrial dynamics and mitophagy are two highly integrated processes in MQC system that determines whether damaged mitochondria will be repaired or degraded. Neurons are highly differentiated cells which demand high energy consumption. Therefore, compromised MQC processes and the accumulation of dysfunctional mitochondria may be the main cause of neuronal death and lead to neurodegeneration. Here, we focus on the inseparable relationship of mitochondria dynamics and mitophagy and how their dysfunction may lead to neurodegenerative diseases.