Genetics of atherosclerosis.

Genetics of atherosclerosis.
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DOI:
10.1016/j.tig.2012.03.001
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发表时间:
2012-06
期刊:
影响因子:
11.4
通讯作者:
Lusis, Aldons J.
Lusis, Aldons J.
中科院分区:
生物学1区
文献类型:
--
作者:
Lusis, Aldons J.

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过去几年的全基因组关联研究(GWAS)首次提供了欧洲和一些亚洲人群中常见心血管疾病特征基因的无偏倚证据。结果不仅证实了先前知识的重要性,例如脂蛋白的核心作用,而且还揭示了关于这种疾病的潜在机制还有很多东西要了解,因为大多数相关基因似乎并不参与先前与动脉粥样硬化相关的途径。在这篇综述中,我重点介绍了这种疾病的常见形式,并研究了人类和动物模型研究。我总结了GWAS之前所知的内容,强调了GWAS如何改变了该领域,并讨论了未来的考虑因素,例如GWAS的局限性和可能导致更完整的动脉粥样硬化机制理解的策略。
Genome-wide association studies (GWAS) from the past several years have provided the first unbiased evidence of the genes contributing to common cardiovascular disease traits in European and some Asian populations. The results not only confirmed the importance of prior knowledge, such as the central role of lipoproteins, but also revealed that there is still much to learn about the underlying mechanisms of this disease, as most of the associated genes do not appear to be involved in pathways previously connected to atherosclerosis. In this review, I focus on the common forms of the disease and look at both human and animal model studies. I summarize what was known before GWAS, highlight how the field has been changed by GWAS, and discuss future considerations, such as the limitations of GWAS and strategies that may lead to a more complete, mechanistic understanding of atherosclerosis.
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