123I-FP-Cit and 123I-IBZM SPECT uptake in a prospective normal material analysed with two different semiquantitative image evaluation tools
123I-FP-Cit and 123I-IBZM SPECT uptake in a prospective normal material analysed with two different semiquantitative image evaluation tools
复制标题
DOI：
10.1097/mnm.0b013e328364aa2e
复制
发表时间：
2013-10-01
影响因子：
1.5
通讯作者：
Riklund, Katrine
中科院分区：
文献类型：
--
作者：
Mo, Susanna Jakobson;Larsson, Anne;Riklund, Katrine
目的探讨帕金森病患者单光子发射计算机断层显像（SPECT）多巴胺转运体（DAT）和多巴胺D2受体（D2 R）显像中是否需要调整年龄和/或性别的参考值。我们使用了两种不同的图像评价工具，横截面和纵向statistical approach.Materials和方法基线DAT和/或D2 R SPECT进行了51例健康对照（HC），年龄匹配的患者在一个正在进行的前瞻性研究特发性帕金森氏症。24例HC在3年后复查，21例HC在5年后复查。在双头混合伽马照相机上用I-123-FP-Cit和I-123-IBZM进行SPECT。使用感兴趣区域和感兴趣体积（VOI）进行图像评价。横截面和纵向statistical analysis.Results较少的性别差异和较少的年龄依赖性被认为是DAT SPECT摄取率相比，D2 R SPECT摄取率，并比较摄取率获得的感兴趣的区域对那些与VOI。在横断面分析中，在女性中，采用VOI方法的DAT和D2 R摄取量均出现显著的年龄依赖性下降，但在男性中，采用任何一种评估方法均未出现这种情况。在纵向数据集，随着时间的推移，略有下降和增加，在DAT摄取，但是，一般模式的减少被认为是在男性和女性在D2 R uptake.Conclusion图像评价方法的选择可以影响模式的性别和年龄相关的差异。结果表明，使用年龄分层的参考值的妇女，特别是当使用VOI方法。
Objective The need for age-adjusted and/or sex-adjusted reference values in dopamine transporter (DAT) and dopamine D2 receptor (D2R) imaging with single-photon emission computed tomography (SPECT) in a longitudinal study of parkinsonian diseases was investigated. We used two different image evaluation tools with a cross-sectional and longitudinal statistical approach.Materials and methods Baseline DAT and/or D2R SPECT were performed in 51 healthy controls (HC), age-matched to patients in an ongoing prospective study on idiopathic parkinsonism. Twenty-four HC were re-examined after 3 years and 21 HC were examined again after 5 years. SPECT was performed with I-123-FP-Cit and I-123-IBZM on a two-headed hybrid gamma camera. Regions of interest and volumes of interest (VOIs) were used for image evaluation. A cross-sectional and longitudinal statistical analysis was carried out.Results Fewer sex-based differences and less age dependency were seen in DAT SPECT uptake ratios compared with D2R SPECT uptake ratios and when comparing uptake ratios obtained with regions of interest against those with VOIs. In the cross-sectional analysis, a significant age-dependent decline was seen in women in both DAT and D2R uptakes with the VOI method but not in men with either evaluation method. In the longitudinal dataset, both a slight decline and increase over time were seen in DAT uptake; however, a general pattern of decrease was seen in both men and women in D2R uptake.Conclusion The choice of the image evaluation method can influence the pattern of sex-based and age-related differences. The results speak for the use of age-stratified reference values for women, in particular when using a VOI method.