Disproportionality by sex in the prescription of drugs capable of inducing parkinsonism for the elderly: A survey using statistics of Japanese national health claims from 2014 to 2017
Disproportionality by sex in the prescription of drugs capable of inducing parkinsonism for the elderly: A survey using statistics of Japanese national health claims from 2014 to 2017
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老年人帕金森病药物处方中的性别比例失调：利用 2014 年至 2017 年日本国民健康声称统计数据进行的调查
DOI：
10.1111/ncn3.12501
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发表时间：
2021
影响因子：
0.4
通讯作者：
Toda T
中科院分区：
文献类型：
--
作者：
Sato K;Mano T;Iwata A;Toda T
背景已知年龄较大和女性患者发生药物诱导的帕金森综合征（DIP）的风险增加。目的与引起DIP风险相关的药物的基本处方模式尚不清楚，我们在本研究中进行了评估。方法使用公开分发的数据“NDB Open Data Japan”，对日本全国范围内的健康索赔进行汇总统计，我们计算了2014年至2017年在门诊处方片剂/胶囊的不同年龄组男性和女性的处方重复性。基于2 × 2列联表，我们推导出比值比（OR），以确定老年（65岁）女性比男性更常使用哪种药物。结果在我们调查的18种通用DIP相关药物的计算OR中，舒必利的OR最高（3.85），其次为硫必利（OR = 2.47）、奥氮平（OR = 2.43）和利培酮（OR = 2.27）。在所有的药物产品包括在数据库中，舒必利再次表现出显着的高OR，这是高于第95百分位数的OR的所有3604 productsexamined.ConclusionOur结果表明，舒必利处方的分布偏向老年女性，谁更容易发展DIP比男性。假设舒必利作为抑郁症或精神分裂症的主要治疗选择的适应症有限，未来关于舒必利为何以及如何处方给老年女性患者的研究可能有助于改变舒必利的处方策略，从而可能降低日本DIP的总体发生率。
BackgroundPatients with older age and female sex are known to have increased risk of developing drug‐induced parkinsonism (DIP).AimBasic prescription patterns of drugs associated with a risk of causing DIP remain unclear, which we assessed in this study.MethodsUsing the publicly distributed data “NDB Open Data Japan,” the summary statistics of Japanese nationwide health claims, we calculated the disproportionality in prescriptions among men and women of different age groups to whom tablets/capsules were prescribed at the outpatient clinic from 2014 to 2017. Based on the 2‐by‐2 contingency table, we derived the odds ratio (OR) to identify which drug is more frequently prescribed to elderly (65 y/o) women than to men.ResultsAmong the calculated ORs of 18 generic DIP‐related drugs we investigated, sulpiride had the highest OR (3.85), followed by tiapride (OR = 2.47), olanzapine (OR = 2.43), and risperidone (OR = 2.27). Among all the drug products included in the database, sulpiride again showed a significantly high OR, which was higher than the 95th percentile of ORs of all 3604 products examined.ConclusionOur results showed that the distribution of sulpiride prescriptions is biased toward older females, who are more susceptible to develop DIP than males. Assuming the limited indication of sulpiride as the primary treatment option for depression or schizophrenia, a future study on why and how sulpiride is prescribed to the elderly female patients might aid in changing the prescription strategy of sulpiride, thereby possibly reducing the overall incidence of DIP in Japan.
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精神分裂症难治性精神分裂症药物治疗指南
DOI：
--
发表时间：
2019
期刊：
--
影响因子：
--
作者：
Y. Matsui
通讯作者：
Y. Matsui
了解药物引起的帕金森病
影响因子：
9.9
作者：
M. Alvarez;V. Evidente
通讯作者：
V. Evidente
DOI：
--
发表时间：
2022
期刊：
影响因子：
--
作者：
Fujioka I;Ohtsu H;Yonemoto N;Sase K;Murashima A.
通讯作者：
Murashima A.
DOI：
10.3143/geriatrics.44.31
发表时间：
2007-01-01
期刊：
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
影响因子：
--
作者：
Akishita, Masahiro
通讯作者：
Akishita, Masahiro
【摘自《2015年老年人就医及其安全指南》】
DOI：
--
发表时间：
2016
期刊：
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
影响因子：
--
作者：
K. Mizukami
通讯作者：
K. Mizukami