The pantheon of the fallen: why are there so many forms of cell death?

The pantheon of the fallen: why are there so many forms of cell death?
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DOI:
10.1016/j.tcb.2012.08.008
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发表时间:
2012-11
影响因子:
19
通讯作者:
Victor, Bernadette
Victor, Bernadette
中科院分区:
生物学1区
文献类型:
--
作者:
Green, Douglas R.;Victor, Bernadette

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细胞死亡的机制有多种,但只有其中一些机制已被详细阐明。细胞死亡存在多种“主动”形式,其中细胞参与自身死亡,包括细胞凋亡、程序性坏死、有丝分裂灾难和最近描述的铁死亡等过程。在这里,我们试图解释为什么有如此多种不同形式的细胞死亡,并提出“自杀”与“破坏”主动死亡之间的区别。
Cells die by a variety of mechanisms, only some of which have been elucidated in detail. A number of `active' forms of cell death exist in which the cell participates in its own death, including apoptosis, programmed necrosis, mitotic catastrophe, and the recently described ferroptosis, among other processes. Here, we attempt to explain why there are so many different forms of cell death, and propose a distinction between active death that is `suicide' versus `sabotage.'
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